Basic Information
ID: ALA4046967
Type: Binding
Description: Inhibition of human topoisomerase-2 alpha assessed as reduction in conversion of super coiled plasmid DNA to relaxed DNA at 20 uM using supercoiled pBR322 DNA as substrate after 30 mins by ethidium bromide staining based agarose gel electrophoresis method relative to control
Format: BAO_0000357
Organism: Homo sapiens
Target: DNA topoisomerase II alpha(ALA1806)
Document: ALA4043212
Inhibition of human topoisomerase-2 alpha assessed as reduction in conversion of super coiled plasmid DNA to relaxed DNA at 20 uM using supercoiled pBR322 DNA as substrate after 30 mins by ethidium bromide staining based agarose gel electrophoresis method relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4046967
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 588.56 | 1.34 | 1.34 |
| 405.50 | 6.19 | 6.19 |