Basic Information
ID: ALA4047811
Type: Functional
Description: Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured after 1.7 mins by Fluo-4 AM dye based fluorescence assay
Format: BAO_0000219
Organism: Rattus norvegicus
Target: Metabotropic glutamate receptor 5(ALA2564)
Document: ALA4043265
Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured after 1.7 mins by Fluo-4 AM dye based fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4047811
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 351.30 | 2.10 | 2.10 |
| 416.32 | 3.30 | 3.30 |
| 367.32 | 3.45 | 3.45 |
| 384.76 | 3.36 | 3.36 |
| 368.30 | 2.84 | 2.84 |
| 367.32 | 3.45 | 3.45 |
| 363.35 | 3.62 | 3.62 |
| 386.29 | 2.98 | 2.98 |
| 351.30 | 2.10 | 2.10 |
| 363.35 | 3.62 | 3.62 |
| 368.30 | 2.84 | 2.84 |
| 375.32 | 2.57 | 2.57 |
| 386.29 | 2.98 | 2.98 |
| 382.33 | 3.15 | 3.15 |
| 382.33 | 3.15 | 3.15 |
| 386.29 | 2.98 | 2.98 |
| 379.35 | 3.32 | 3.32 |