Drug level in mouse liver microsomes treated with (R)-2-methyl-N1-((S)-11-oxo-1,2,3,5,10,11-hexahydrobenzo[d]pyrazolo[1,2-a][1,2]diazepin-10-yl)-N4-o-...

ID: ALA4048223

Type: ADME

Description: Drug level in mouse liver microsomes treated with (R)-2-methyl-N1-((S)-11-oxo-1,2,3,5,10,11-hexahydrobenzo[d]pyrazolo[1,2-a][1,2]diazepin-10-yl)-N4-o-tolylsuccinamide assessed as compound formation at 2 mM preincubated for 3 mins followed by NADPH addition measured after 1 hr in presence of GSH and [13C2-15N-glycine]-GSH by HPLC/MS method

Format: BAO_0000019

Organism: Mus musculus

Tissue: Liver

Subcellular Fraction:  microsome

Target:  Liver(ALA613580)

Document:  ALA4043282

Drug level in mouse liver microsomes treated with (R)-2-methyl-N1-((S)-11-oxo-1,2,3,5,10,11-hexahydrobenzo[d]pyrazolo[1,2-a][1,2]diazepin-10-yl)-N4-o-tolylsuccinamide assessed as compound formation at 2 mM preincubated for 3 mins followed by NADPH addition measured after 1 hr in presence of GSH and [13C2-15N-glycine]-GSH by HPLC/MS method: 1