Basic Information
ID: ALA4048560
Type: Binding
Description: Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis at 3 uM pretreated for 24 hrs followed by TNF and zVAD.fmk addition measured after 3 hrs by Hoechst 33342/propidium iodide staining-based assay relative to control
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA4048560
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 475.60 | 4.90 | 4.90 |
| 520.71 | 4.98 | 4.98 |
| 461.57 | 3.40 | 3.40 |
| 450.57 | 4.14 | 4.14 |
| 490.62 | 3.66 | 3.66 |
| 507.67 | 4.07 | 4.07 |
| 489.63 | 5.21 | 5.21 |
| 464.60 | 4.45 | 4.45 |
| 503.66 | 4.57 | 4.57 |
| 479.61 | 3.21 | 3.21 |
| 449.52 | 2.88 | 2.88 |
| 507.66 | 5.07 | 5.07 |
| 505.69 | 6.22 | 6.22 |
| 446.56 | 4.64 | 4.64 |
| 504.64 | 3.97 | 3.97 |
| 448.54 | 2.49 | 2.49 |
| 447.55 | 4.04 | 4.04 |
| 521.70 | 4.38 | 4.38 |
| 492.65 | 4.20 | 4.20 |
| 488.64 | 5.81 | 5.81 |
| 448.53 | 3.49 | 3.49 |
| 506.68 | 5.62 | 5.62 |
| 491.60 | 4.05 | 4.05 |
| 433.52 | 3.73 | 3.73 |
| 466.57 | 3.29 | 3.29 |
| 462.56 | 2.80 | 2.80 |
| 490.61 | 4.66 | 4.66 |
| 508.65 | 4.46 | 4.46 |
| 506.68 | 4.67 | 4.67 |
| 492.65 | 5.31 | 5.31 |
| 477.57 | 3.75 | 3.75 |