Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76V...

Basic Information

ID: ALA4049702

Type: Binding

Description: Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76V-GFP assessed as reduction in UbG76V-GFP degradation rate by fluorescence microscopic method

Format: BAO_0000219

Organism: Homo sapiens

Cell type: HeLa

Target: 26S proteasome non-ATPase regulatory subunit 14(ALA2007629)

Document: ALA4049386

Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76V-GFP assessed as reduction in UbG76V-GFP degradation rate by fluorescence microscopic method: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4049702

IC50

Total(27)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
632.81	3.71	3.71
674.76	6.90	6.90
588.72	6.23	6.23
540.59	6.06	6.06
722.74	9.48	9.48
329.45	3.39	3.39
572.72	7.00	7.00
628.83	6.44	6.44
406.49	3.78	3.78
622.72	7.72	7.72
816.92	4.76	4.76
588.72	6.23	6.23
630.81	5.23	5.23
550.62	3.39	3.39
754.98	8.27	8.27
299.36	2.37	2.37
574.73	5.40	5.40
600.78	6.36	6.36
586.74	7.44	7.44
566.66	6.63	6.63
646.79	7.46	7.46
594.72	6.71	6.71
626.85	7.65	7.65
628.83	6.44	6.44
434.55	4.30	4.30
588.72	6.23	6.23
598.80	7.57	7.57