Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated f...

Basic Information

ID: ALA4049704

Type: Binding

Description: Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated for 1 hr followed by substrate addition measured after 80 mins by fluorescence polarization assay

Format: BAO_0000219

Organism: Homo sapiens

Target: 26S proteasome non-ATPase regulatory subunit 14(ALA2007629)

Document: ALA4049386

Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated for 1 hr followed by substrate addition measured after 80 mins by fluorescence polarization assay: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4049704

IC50

Total(50)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
145.16	1.94	1.94
144.18	1.82	1.82
143.19	2.54	2.54
632.81	3.71	3.71
674.76	6.90	6.90
588.72	6.23	6.23
175.26	2.83	2.83
540.59	6.06	6.06
408.46	4.98	4.98
586.74	7.44	7.44
722.74	9.48	9.48
162.22	1.92	1.92
329.45	3.39	3.39
572.72	7.00	7.00
628.83	6.44	6.44
408.46	4.98	4.98
161.23	2.52	2.52
161.23	2.52	2.52
175.26	2.96	2.96
436.51	5.16	5.16
406.49	3.78	3.78
598.80	7.57	7.57
622.72	7.72	7.72
816.92	4.76	4.76
175.26	2.83	2.83
588.72	6.23	6.23
175.26	2.83	2.83
630.81	5.23	5.23
436.51	5.16	5.16
550.62	3.39	3.39
598.80	7.57	7.57
754.98	8.27	8.27
299.36	2.37	2.37
574.73	5.40	5.40
436.51	5.16	5.16
408.46	4.98	4.98
600.78	6.36	6.36
160.24	3.13	3.13
586.74	7.44	7.44
566.66	6.63	6.63
646.79	7.46	7.46
566.66	6.63	6.63
594.72	6.71	6.71
626.85	7.65	7.65
175.26	2.83	2.83
175.26	2.83	2.83
628.83	6.44	6.44
434.55	4.30	4.30
588.72	6.23	6.23
598.80	7.57	7.57