Basic Information
ID: ALA4051532
Type: Binding
Description: Inhibition of human BRPF2 (563 to 688 residues) expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,12 diacetylated histone H4 (1 to 20 residues) peptide as substrate measured after 1 hr by TR-FRET assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Bromodomain-containing protein 1(ALA2176774)
Document: ALA4049437
Inhibition of human BRPF2 (563 to 688 residues) expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,12 diacetylated histone H4 (1 to 20 residues) peptide as substrate measured after 1 hr by TR-FRET assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4051532
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 380.45 | 2.74 | 2.74 |
| 443.50 | 3.45 | 3.45 |
| 428.49 | 3.96 | 3.96 |
| 440.50 | 3.74 | 3.74 |
| 526.64 | 2.82 | 2.82 |
| 455.52 | 2.58 | 2.58 |
| 400.44 | 2.90 | 2.90 |
| 470.53 | 3.10 | 3.10 |
| 401.42 | 2.75 | 2.75 |
| 456.50 | 2.98 | 2.98 |
| 416.39 | 3.05 | 3.05 |
| 469.55 | 2.89 | 2.89 |
| 405.84 | 3.79 | 3.79 |
| 436.27 | 3.59 | 3.59 |
| 509.61 | 3.67 | 3.67 |
| 386.41 | 2.72 | 2.72 |
| 387.40 | 2.84 | 2.84 |
| 357.37 | 2.83 | 2.83 |
| 387.40 | 2.84 | 2.84 |
| 450.29 | 3.90 | 3.90 |
| 429.48 | 3.06 | 3.06 |
| 450.29 | 3.90 | 3.90 |
| 497.60 | 3.67 | 3.67 |
| 454.53 | 4.13 | 4.13 |
| 371.40 | 3.14 | 3.14 |
| 396.41 | 3.01 | 3.01 |
| 484.56 | 3.75 | 3.75 |