Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra-...

Basic Information

ID: ALA4051536

Type: Binding

Description: Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra-acetylated histone H4 (1 to 20 residues) peptide as substrate measured after 1 hr by TR-FRET assay

Format: BAO_0000357

Organism: Homo sapiens

Target: Bromodomain-containing protein 4(ALA1163125)

Document: ALA4049437

Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra-acetylated histone H4 (1 to 20 residues) peptide as substrate measured after 1 hr by TR-FRET assay: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4051536

IC50

Total(27)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
380.45	2.74	2.74
443.50	3.45	3.45
428.49	3.96	3.96
440.50	3.74	3.74
526.64	2.82	2.82
455.52	2.58	2.58
400.44	2.90	2.90
470.53	3.10	3.10
401.42	2.75	2.75
456.50	2.98	2.98
416.39	3.05	3.05
469.55	2.89	2.89
405.84	3.79	3.79
436.27	3.59	3.59
509.61	3.67	3.67
386.41	2.72	2.72
387.40	2.84	2.84
357.37	2.83	2.83
387.40	2.84	2.84
450.29	3.90	3.90
429.48	3.06	3.06
450.29	3.90	3.90
497.60	3.67	3.67
454.53	4.13	4.13
371.40	3.14	3.14
396.41	3.01	3.01
484.56	3.75	3.75