Basic Information
ID: ALA4052343
Type: Binding
Description: Irreversible inhibition of human LOXL2 assessed as reduction of H2O2 production from oxidative deamination of DAP at 1000 times IC50 preincubated for 2 hrs followed by compound washout and subsequent incubation for 2 hrs prior to substrate addition measured every 2 mins for 40 mins by amplex red reagent-based fluorescence assay relative to control
Format: BAO_0000357
Organism: Homo sapiens
Target: Lysyl oxidase homolog 2(ALA3714029)
Document: ALA4049456
Irreversible inhibition of human LOXL2 assessed as reduction of H2O2 production from oxidative deamination of DAP at 1000 times IC50 preincubated for 2 hrs followed by compound washout and subsequent incubation for 2 hrs prior to substrate addition measured every 2 mins for 40 mins by amplex red reagent-based fluorescence assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4052343
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 70.09 | -0.14 | -0.14 |
| 423.82 | 4.60 | 4.60 |
| 367.81 | 1.49 | 1.49 |
| 142.59 | 1.19 | 1.19 |
| 417.82 | 2.56 | 2.56 |
| 435.81 | 2.51 | 2.51 |
| 443.82 | 1.77 | 1.77 |
| 454.86 | 1.37 | 1.37 |
| 367.81 | 1.49 | 1.49 |
| 421.80 | 1.43 | 1.43 |