Basic Information
ID: ALA4052480
Type: Binding
Description: Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain expressed in baculovirus expression system preincubated for 20 mins followed by addition of [33P]-ATP measured after 2 hrs by filter-binding method
Format: BAO_0000019
Organism: Homo sapiens
Target: Epidermal growth factor receptor erbB1(ALA203)
Document: ALA4049460
Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain expressed in baculovirus expression system preincubated for 20 mins followed by addition of [33P]-ATP measured after 2 hrs by filter-binding method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4052480
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 466.54 | 4.35 | 4.35 |
| 446.49 | 6.80 | 6.80 |
| 354.39 | 5.43 | 5.43 |
| 430.49 | 7.09 | 7.09 |
| 398.44 | 4.96 | 4.96 |
| 459.55 | 5.97 | 5.97 |
| 297.75 | 4.01 | 4.01 |
| 445.50 | 6.68 | 6.68 |
| 455.44 | 4.69 | 4.69 |
| 428.50 | 6.66 | 6.66 |
| 418.46 | 6.25 | 6.25 |
| 481.53 | 5.48 | 5.48 |
| 499.55 | 7.22 | 7.22 |
| 483.55 | 5.70 | 5.70 |
| 501.57 | 7.44 | 7.44 |
| 427.51 | 4.55 | 4.55 |
| 277.33 | 3.03 | 3.03 |
| 336.37 | 3.68 | 3.68 |
| 426.50 | 5.74 | 5.74 |
| 570.67 | 6.83 | 6.83 |
| 501.57 | 7.44 | 7.44 |
| 499.55 | 7.22 | 7.22 |
| 446.49 | 6.80 | 6.80 |
| 429.52 | 4.77 | 4.77 |
| 513.58 | 6.90 | 6.90 |
| 513.58 | 6.90 | 6.90 |