Basic Information
ID: ALA4055896
Type: Binding
Description: Inhibition of acid-induced wild type transthyretin (unknown origin) aggregation expressed in Escherichia coli pre-incubated for 30 mins before acid addition and further incubated for 72 hrs at 37 degC under dark conditions by UV-Vis spectrophotometry
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4055896
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 296.15 | 4.74 | 4.74 |
| 224.26 | 3.56 | 3.56 |
| 154.21 | 3.35 | 3.35 |
| 282.13 | 4.44 | 4.44 |
| 281.23 | 4.15 | 4.15 |
| 241.29 | 3.75 | 3.75 |
| 250.20 | 3.04 | 3.04 |
| 228.25 | 2.97 | 2.97 |
| 170.21 | 3.06 | 3.06 |
| 323.99 | 5.38 | 5.38 |
| 214.22 | 2.76 | 2.76 |
| 267.11 | 4.36 | 4.36 |
| 198.22 | 3.05 | 3.05 |
| 266.22 | 4.07 | 4.07 |
| 216.21 | 3.19 | 3.19 |
| 230.26 | 2.59 | 2.59 |
| 234.20 | 3.33 | 3.33 |
| 216.21 | 3.19 | 3.19 |
| 216.21 | 3.19 | 3.19 |
| 172.20 | 3.49 | 3.49 |
| 188.20 | 3.20 | 3.20 |
| 206.19 | 3.34 | 3.34 |
| 234.20 | 3.33 | 3.33 |
| 188.20 | 3.20 | 3.20 |
| 283.11 | 4.06 | 4.06 |
| 283.11 | 4.06 | 4.06 |
| 250.20 | 3.04 | 3.04 |
| 234.20 | 3.33 | 3.33 |
| 234.20 | 3.33 | 3.33 |
| 234.20 | 3.33 | 3.33 |
| 283.11 | 4.06 | 4.06 |
| 250.20 | 3.04 | 3.04 |
| 214.22 | 2.76 | 2.76 |
| 250.20 | 3.04 | 3.04 |
| 232.21 | 2.90 | 2.90 |
| 198.22 | 3.05 | 3.05 |
| 234.20 | 3.33 | 3.33 |
| 223.10 | 4.66 | 4.66 |
| 190.19 | 3.63 | 3.63 |
| 172.20 | 3.49 | 3.49 |
| 170.21 | 3.06 | 3.06 |
| 232.21 | 2.90 | 2.90 |
| 267.11 | 4.36 | 4.36 |
| 267.11 | 4.36 | 4.36 |
| 324.26 | 4.05 | 4.05 |
| 256.26 | 3.03 | 3.03 |
| 291.99 | 5.97 | 5.97 |
| 199.21 | 3.26 | 3.26 |
| 509.04 | 3.71 | 3.71 |
| 310.14 | 4.10 | 4.10 |
| 415.04 | 4.03 | 4.03 |
| 309.24 | 3.82 | 3.82 |
| 509.04 | 3.71 | 3.71 |
| 277.23 | 3.08 | 3.08 |
| 310.14 | 4.10 | 4.10 |
| 415.04 | 4.03 | 4.03 |
| 309.24 | 3.82 | 3.82 |
| 277.23 | 3.08 | 3.08 |
| 501.01 | 4.29 | 4.29 |
| 309.24 | 3.82 | 3.82 |
| 407.01 | 4.61 | 4.61 |
| 277.23 | 3.08 | 3.08 |
| 310.14 | 4.10 | 4.10 |
| 310.14 | 4.10 | 4.10 |
| 509.04 | 3.71 | 3.71 |
| 415.04 | 4.03 | 4.03 |
| 310.14 | 4.10 | 4.10 |
| 439.92 | 5.64 | 5.64 |
| 309.24 | 3.82 | 3.82 |
| 309.24 | 3.82 | 3.82 |
| 533.02 | 5.03 | 5.03 |
| 371.03 | 4.33 | 4.33 |
| 310.14 | 4.10 | 4.10 |
| 533.02 | 5.03 | 5.03 |
| 439.02 | 5.35 | 5.35 |
| 465.03 | 4.01 | 4.01 |
| 310.14 | 4.10 | 4.10 |
| 439.02 | 5.35 | 5.35 |
| 533.92 | 5.32 | 5.32 |
| 196.25 | 3.56 | 3.56 |
| 242.32 | 4.00 | 4.00 |
| 256.26 | 3.03 | 3.03 |
| 308.12 | 4.50 | 4.50 |
| 298.13 | 4.14 | 4.14 |
| 422.93 | 6.39 | 6.39 |
| 424.95 | 6.01 | 6.01 |
| 369.06 | 4.67 | 4.67 |
| 368.07 | 4.55 | 4.55 |
| 368.07 | 4.55 | 4.55 |
| 413.11 | 4.98 | 4.98 |
| 342.44 | 6.33 | 6.33 |
| 307.99 | 5.67 | 5.67 |
| 214.22 | 3.34 | 3.34 |
| 384.07 | 5.10 | 5.10 |
| 432.94 | 5.85 | 5.85 |
| 370.08 | 5.01 | 5.01 |
| 424.05 | 5.72 | 5.72 |
| 416.11 | 4.72 | 4.72 |
| 198.26 | 3.18 | 3.18 |
| 224.26 | 3.56 | 3.56 |
| 308.12 | 4.50 | 4.50 |
| 214.22 | 3.18 | 3.18 |
| 198.26 | 3.18 | 3.18 |
| 196.25 | 3.56 | 3.56 |
| 198.22 | 3.05 | 3.05 |
| 342.44 | 6.33 | 6.33 |
| 368.07 | 5.40 | 5.40 |
| 370.08 | 5.01 | 5.01 |
| 307.23 | 4.21 | 4.21 |
| 376.88 | 6.98 | 6.98 |
| 479.94 | 5.69 | 5.69 |
| 490.04 | 7.13 | 7.13 |
| 362.27 | 5.21 | 5.21 |
| 374.05 | 4.84 | 4.84 |
| 415.32 | 5.74 | 5.74 |
| 422.04 | 6.11 | 6.11 |
| 415.32 | 5.74 | 5.74 |
| 418.08 | 6.90 | 6.90 |
| 416.22 | 6.03 | 6.03 |
| 416.11 | 4.72 | 4.72 |
| 417.20 | 6.08 | 6.08 |
| 385.06 | 4.47 | 4.47 |
| 244.29 | 5.25 | 5.25 |
| 308.12 | 4.50 | 4.50 |
| 336.26 | 4.27 | 4.27 |
| 374.05 | 4.84 | 4.84 |
| 295.21 | 5.10 | 5.10 |
| 370.04 | 4.79 | 4.79 |
| 391.34 | 4.42 | 4.42 |
| 275.21 | 3.47 | 3.47 |
| 386.08 | 4.71 | 4.71 |
| 374.05 | 4.84 | 4.84 |
| 211.31 | 3.92 | 3.92 |
| 390.02 | 5.37 | 5.37 |
| 416.22 | 6.03 | 6.03 |
| 360.25 | 5.59 | 5.59 |
| 370.04 | 4.79 | 4.79 |
| 400.31 | 5.67 | 5.67 |
| 516.93 | 6.08 | 6.08 |
| 416.31 | 5.79 | 5.79 |
| 403.46 | 5.38 | 5.38 |
| 398.05 | 4.79 | 4.79 |
| 388.49 | 5.74 | 5.74 |
| 366.76 | 5.30 | 5.30 |
| 388.49 | 5.74 | 5.74 |
| 479.94 | 5.69 | 5.69 |
| 239.23 | 3.19 | 3.19 |
| 307.23 | 4.21 | 4.21 |
| 511.83 | 6.61 | 6.61 |
| 432.94 | 5.85 | 5.85 |
| 286.28 | 2.57 | 2.57 |
| 410.92 | 6.10 | 6.10 |
| 422.93 | 6.39 | 6.39 |
| 239.23 | 3.19 | 3.19 |
| 363.18 | 3.41 | 3.41 |
| 398.05 | 4.79 | 4.79 |
| 259.31 | 5.33 | 5.33 |
| 398.05 | 4.79 | 4.79 |
| 304.35 | 5.70 | 5.70 |
| 370.08 | 5.01 | 5.01 |
| 308.12 | 4.50 | 4.50 |
| 401.05 | 4.61 | 4.61 |
| 227.31 | 3.62 | 3.62 |
| 284.27 | 3.73 | 3.73 |
| 368.29 | 4.93 | 4.93 |
| 275.21 | 3.47 | 3.47 |
| 392.04 | 4.98 | 4.98 |
| 497.46 | 5.06 | 5.06 |
| 307.23 | 4.21 | 4.21 |
| 304.25 | 3.53 | 3.53 |
| 371.07 | 4.28 | 4.28 |
| 284.27 | 2.96 | 2.96 |
| 390.50 | 5.36 | 5.36 |
| 286.33 | 3.66 | 3.66 |
| 306.26 | 3.15 | 3.15 |
| 350.30 | 4.79 | 4.79 |
| 307.23 | 4.21 | 4.21 |
| 357.05 | 4.53 | 4.53 |
| 399.04 | 4.16 | 4.16 |
| 357.05 | 4.53 | 4.53 |
| 381.77 | 5.38 | 5.38 |
| 449.77 | 6.40 | 6.40 |
| 399.04 | 5.00 | 5.00 |
| 294.27 | 4.19 | 4.19 |
| 307.23 | 4.21 | 4.21 |
| 336.26 | 4.27 | 4.27 |
| 414.09 | 5.10 | 5.10 |
| 402.04 | 4.44 | 4.44 |
| 308.12 | 4.50 | 4.50 |
| 309.24 | 3.66 | 3.66 |
| 339.17 | 4.18 | 4.18 |
| 382.10 | 5.70 | 5.70 |
| 239.23 | 3.19 | 3.19 |
| 308.12 | 4.50 | 4.50 |
| 386.04 | 4.50 | 4.50 |
| 434.08 | 6.61 | 6.61 |
| 384.11 | 5.32 | 5.32 |
| 384.07 | 5.10 | 5.10 |
| 337.16 | 4.56 | 4.56 |
| 426.22 | 5.49 | 5.49 |
| 390.50 | 5.36 | 5.36 |
| 293.19 | 5.49 | 5.49 |
| 307.23 | 4.21 | 4.21 |
| 308.12 | 4.50 | 4.50 |
| 326.44 | 6.62 | 6.62 |
| 298.56 | 5.46 | 5.46 |
| 366.76 | 5.30 | 5.30 |
| 376.32 | 4.35 | 4.35 |
| 227.31 | 3.62 | 3.62 |
| 350.30 | 4.79 | 4.79 |
| 240.26 | 3.26 | 3.26 |
| 260.29 | 5.38 | 5.38 |
| 432.94 | 5.85 | 5.85 |
| 216.21 | 3.19 | 3.19 |
| 424.05 | 5.72 | 5.72 |
| 370.04 | 4.79 | 4.79 |
| 348.31 | 4.77 | 4.77 |
| 272.35 | 5.87 | 5.87 |
| 479.94 | 5.69 | 5.69 |
| 369.06 | 4.67 | 4.67 |
| 383.31 | 5.00 | 5.00 |
| 381.77 | 5.38 | 5.38 |
| 371.07 | 4.28 | 4.28 |
| 384.29 | 5.05 | 5.05 |
| 423.03 | 5.48 | 5.48 |
| 382.10 | 5.70 | 5.70 |
| 275.21 | 3.47 | 3.47 |
| 341.05 | 4.82 | 4.82 |
| 390.50 | 5.36 | 5.36 |
| 324.26 | 4.05 | 4.05 |
| 384.07 | 5.10 | 5.10 |
| 392.04 | 4.98 | 4.98 |
| 268.27 | 3.25 | 3.25 |
| 371.07 | 4.28 | 4.28 |
| 318.18 | 3.50 | 3.50 |
| 418.08 | 6.48 | 6.48 |
| 384.11 | 5.32 | 5.32 |
| 406.93 | 6.69 | 6.69 |
| 506.10 | 6.30 | 6.30 |
| 399.04 | 5.00 | 5.00 |
| 229.67 | 4.15 | 4.15 |
| 341.05 | 4.82 | 4.82 |
| 483.32 | 6.76 | 6.76 |
| 372.03 | 5.23 | 5.23 |
| 365.32 | 4.87 | 4.87 |
| 386.08 | 4.71 | 4.71 |
| 416.07 | 4.57 | 4.57 |
| 372.03 | 5.23 | 5.23 |
| 307.23 | 4.21 | 4.21 |
| 423.92 | 5.77 | 5.77 |
| 372.03 | 5.23 | 5.23 |
| 468.31 | 6.69 | 6.69 |
| 307.99 | 5.67 | 5.67 |
| 332.31 | 4.65 | 4.65 |
| 376.32 | 4.35 | 4.35 |
| 402.08 | 6.78 | 6.78 |
| 239.23 | 3.19 | 3.19 |
| 275.21 | 3.47 | 3.47 |
| 324.26 | 4.05 | 4.05 |
| 211.31 | 3.92 | 3.92 |
| 390.02 | 5.37 | 5.37 |
| 387.03 | 4.70 | 4.70 |
| 288.35 | 5.58 | 5.58 |
| 338.28 | 3.89 | 3.89 |
| 368.07 | 5.40 | 5.40 |
| 369.06 | 4.67 | 4.67 |
| 511.83 | 6.61 | 6.61 |
| 312.15 | 4.44 | 4.44 |
| 309.24 | 3.66 | 3.66 |
| 391.34 | 4.42 | 4.42 |
| 368.07 | 5.40 | 5.40 |
| 288.35 | 6.00 | 6.00 |
| 386.08 | 4.71 | 4.71 |
| 383.08 | 4.97 | 4.97 |
| 414.09 | 5.10 | 5.10 |
| 342.03 | 4.79 | 4.79 |
| 307.99 | 5.67 | 5.67 |
| 292.26 | 4.57 | 4.57 |
| 401.20 | 5.96 | 5.96 |
| 338.28 | 3.89 | 3.89 |
| 234.20 | 3.33 | 3.33 |
| 422.04 | 6.11 | 6.11 |
| 388.49 | 5.74 | 5.74 |
| 342.44 | 6.33 | 6.33 |
| 265.65 | 4.43 | 4.43 |
| 342.44 | 6.33 | 6.33 |
| 275.21 | 3.47 | 3.47 |
| 347.33 | 4.73 | 4.73 |
| 287.36 | 5.95 | 5.95 |