Basic Information
ID: ALA4056672
Type: Binding
Description: Inhibition of human G9a catalytic domain (913 to 1193 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated H3 (1 to 25 residues) as substrate preincubated for 20 mins in presence of [3H]SAM measured after 2 hrs by scintillation proximity assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Histone-lysine N-methyltransferase, H3 lysine-9 specific 3(ALA6032)
Document: ALA4052719
Inhibition of human G9a catalytic domain (913 to 1193 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated H3 (1 to 25 residues) as substrate preincubated for 20 mins in presence of [3H]SAM measured after 2 hrs by scintillation proximity assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4056672
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 373.50 | 3.00 | 3.00 |
| 345.45 | 2.22 | 2.22 |
| 387.53 | 3.39 | 3.39 |
| 387.53 | 3.25 | 3.25 |
| 386.50 | 2.59 | 2.59 |
| 427.59 | 4.17 | 4.17 |
| 375.47 | 1.58 | 1.58 |
| 373.50 | 3.00 | 3.00 |
| 389.50 | 1.97 | 1.97 |
| 415.54 | 2.77 | 2.77 |
| 385.51 | 3.14 | 3.14 |
| 402.54 | 2.15 | 2.15 |
| 375.47 | 2.21 | 2.21 |
| 417.55 | 3.12 | 3.12 |
| 389.50 | 2.24 | 2.24 |
| 399.54 | 3.90 | 3.90 |
| 373.50 | 3.00 | 3.00 |
| 400.57 | 4.75 | 4.75 |
| 421.55 | 3.79 | 3.79 |
| 407.52 | 3.92 | 3.92 |
| 359.47 | 2.61 | 2.61 |
| 387.53 | 3.61 | 3.61 |
| 399.54 | 3.53 | 3.53 |
| 401.56 | 3.64 | 3.64 |
| 413.57 | 3.92 | 3.92 |
| 415.58 | 4.17 | 4.17 |
| 371.49 | 2.75 | 2.75 |
| 415.58 | 4.39 | 4.39 |
| 401.56 | 3.78 | 3.78 |