Assay Report Card

Basic Information

ID: ALA4121205

Type: Binding

Description: Inhibition of Rickettsia prowazekii N-terminal His6-tagged methionine aminopeptidase 1 expressed in Escherichia coli DLB3 Rosetta cells at 10 uM using Met-AMC as substrate preincubated for 1 hr followed by 30 mins incubation after substrate addition measured after 90 mins in presence of MnCl2 by fluorescence assay relative to control

Organism: Rickettsia prowazekii

Activity Charts

Bioactivity

Activity Types for Assay ALA4121205

Inhibition

Total(288)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
124.10	0.17	0.17
136.15	0.37	0.37
189.17	1.23	1.23
195.22	2.62	2.62
147.14	0.26	0.26
216.24	1.27	1.27
189.17	1.64	1.64
257.07	3.95	3.95
239.23	2.79	2.79
126.11	0.42	0.42
223.30	1.78	1.78
222.63	2.29	2.29
189.17	0.97	0.97
266.27	1.95	1.95
162.15	1.26	1.26
224.26	1.82	1.82
220.30	1.99	1.99
275.74	3.00	3.00
279.28	1.27	1.27
292.32	2.25	2.25
289.32	0.78	0.78
218.21	1.25	1.25
264.31	2.57	2.57
285.17	2.44	2.44
276.36	1.56	1.56
264.31	1.37	1.37
272.36	1.99	1.99
274.31	2.11	2.11
275.38	2.96	2.96
252.30	1.25	1.25
189.17	2.04	2.04
285.26	1.56	1.56
240.72	2.33	2.33
279.28	1.27	1.27
290.39	1.82	1.82
285.17	2.44	2.44
228.30	2.25	2.25
222.25	2.53	2.53
250.28	1.13	1.13
237.35	2.70	2.70
264.31	2.68	2.68
251.67	2.24	2.24
275.38	2.96	2.96
250.28	1.41	1.41
266.33	1.57	1.57
219.20	2.05	2.05
236.30	1.56	1.56
275.16	2.99	2.99
264.31	1.54	1.54
261.25	0.00	0.00
250.28	2.31	2.31
253.28	1.72	1.72
196.21	2.89	2.89
244.21	1.54	1.54
224.24	1.00	1.00
239.26	1.48	1.48
280.30	2.26	2.26
261.35	2.90	2.90
256.31	1.48	1.48
257.32	3.36	3.36
288.33	1.54	1.54
264.35	2.26	2.26
222.29	2.26	2.26
238.27	1.48	1.48
219.26	2.43	2.43
238.27	1.31	1.31
240.26	2.26	2.26
224.25	0.64	0.64
210.21	0.99	0.99
268.31	2.28	2.28
271.36	2.08	2.08
248.35	2.80	2.80
176.24	2.51	2.51
238.72	1.20	1.20
278.38	2.51	2.51
212.21	2.60	2.60
248.31	1.67	1.67
290.35	2.05	2.05
278.33	2.58	2.58
257.07	3.95	3.95
225.23	1.39	1.39
234.28	1.54	1.54
251.29	3.29	3.29
113.12	-0.16	-0.16
218.21	1.11	1.11
288.31	2.78	2.78
286.72	2.39	2.39
225.68	1.76	1.76
278.69	2.73	2.73
210.24	2.21	2.21
242.68	2.50	2.50
275.38	3.21	3.21
264.31	1.22	1.22
298.80	2.10	2.10
266.32	2.26	2.26
241.04	2.20	2.20
298.80	2.15	2.15
278.38	2.51	2.51
266.26	2.08	2.08
167.16	1.10	1.10
150.18	0.60	0.60
250.26	3.00	3.00
288.38	2.18	2.18
252.29	2.05	2.05
237.26	2.64	2.64
242.23	2.35	2.35
228.25	2.06	2.06
278.34	1.85	1.85
275.31	0.99	0.99
268.25	3.13	3.13
216.27	0.43	0.43
292.32	2.25	2.25
189.24	2.20	2.20
245.08	0.82	0.82
294.34	1.02	1.02
292.29	2.80	2.80
224.69	1.15	1.15
252.25	1.81	1.81
276.24	2.38	2.38
253.33	3.45	3.45
206.63	0.43	0.43
246.29	2.56	2.56
367.43	3.16	3.16
235.74	1.61	1.61
219.20	2.05	2.05
275.38	2.96	2.96
202.21	1.91	1.91
294.33	1.64	1.64
165.60	0.84	0.84
232.24	2.87	2.87
264.31	1.47	1.47
265.31	2.48	2.48
283.36	3.24	3.24
268.29	1.11	1.11
242.28	1.65	1.65
248.23	2.57	2.57
239.71	2.06	2.06
223.62	2.69	2.69
258.71	2.47	2.47
280.33	1.72	1.72
260.27	1.92	1.92
236.20	2.70	2.70
193.25	1.79	1.79
202.24	0.04	0.04
175.19	1.20	1.20
264.35	2.17	2.17
222.63	2.09	2.09
270.36	1.74	1.74
261.35	2.70	2.70
227.34	0.96	0.96
209.20	0.97	0.97
266.30	2.73	2.73
278.38	2.65	2.65
251.27	1.59	1.59
264.31	1.52	1.52
263.32	2.10	2.10
234.28	3.44	3.44
243.27	2.15	2.15
264.29	2.93	2.93
286.31	2.98	2.98
268.25	0.55	0.55
242.71	1.71	1.71
226.66	1.37	1.37
201.25	0.63	0.63
269.33	2.93	2.93
250.28	1.65	1.65
261.35	2.65	2.65
256.33	2.83	2.83
242.23	2.38	2.38
240.74	1.78	1.78
296.29	0.54	0.54
236.66	2.20	2.20
299.36	3.35	3.35
278.34	1.61	1.61
236.20	2.70	2.70
267.31	1.05	1.05
292.36	1.65	1.65
187.25	1.99	1.99
240.72	2.33	2.33
292.34	4.12	4.12
286.24	2.66	2.66
292.36	2.17	2.17
291.38	1.92	1.92
286.69	2.46	2.46
275.38	2.90	2.90
276.24	2.38	2.38
264.31	2.04	2.04
224.24	1.30	1.30
223.27	1.72	1.72
256.26	2.68	2.68
278.34	1.86	1.86
411.44	2.70	2.70
232.24	2.87	2.87
291.34	1.32	1.32
256.13	2.52	2.52
220.25	2.09	2.09
261.35	2.70	2.70
282.32	1.50	1.50
205.19	-0.11	-0.11
239.71	2.06	2.06
292.36	2.24	2.24
282.34	2.59	2.59
153.14	1.25	1.25
241.12	0.48	0.48
268.72	3.92	3.92
216.24	2.09	2.09
189.22	1.43	1.43
295.17	2.47	2.47
223.19	-0.69	-0.69
264.28	3.30	3.30
176.18	1.24	1.24
216.27	0.43	0.43
270.75	2.21	2.21
256.33	1.35	1.35
176.17	1.34	1.34
231.28	1.55	1.55
261.28	0.60	0.60
231.25	1.89	1.89
230.29	0.82	0.82
256.31	1.48	1.48
263.33	1.05	1.05
220.30	1.72	1.72
264.28	3.30	3.30
238.69	3.77	3.77
284.77	2.60	2.60
277.35	2.35	2.35
299.14	3.89	3.89
200.31	2.06	2.06
208.14	1.63	1.63
228.68	1.49	1.49
277.30	2.71	2.71
239.26	1.33	1.33
202.21	2.08	2.08
255.25	3.12	3.12
190.20	1.01	1.01
240.27	1.99	1.99
215.28	1.02	1.02
247.32	2.34	2.34
241.70	2.42	2.42
283.74	2.77	2.77
248.30	3.58	3.58
285.33	3.04	3.04
254.27	1.14	1.14
241.68	1.20	1.20
237.25	2.96	2.96
269.78	1.79	1.79
283.74	1.77	1.77
286.31	2.98	2.98
287.39	3.14	3.14
234.28	3.27	3.27
261.25	3.03	3.03
289.40	3.47	3.47
266.28	0.77	0.77
319.22	2.50	2.50
204.19	0.08	0.08
218.28	3.42	3.42
275.31	3.42	3.42
292.17	1.09	1.09
242.30	0.96	0.96
284.77	1.84	1.84
234.28	1.05	1.05
216.27	0.43	0.43
285.17	2.08	2.08
304.38	3.53	3.53
239.71	2.06	2.06
207.59	2.01	2.01
190.16	1.43	1.43
294.34	1.10	1.10
255.32	2.02	2.02
285.94	2.97	2.97
220.30	1.99	1.99
236.66	2.53	2.53
205.21	2.18	2.18
280.35	2.65	2.65
270.34	2.11	2.11
235.27	1.72	1.72
160.18	1.05	1.05
246.22	2.37	2.37
190.18	1.99	1.99
292.41	2.86	2.86
193.18	1.33	1.33
145.16	1.47	1.47
273.14	4.42	4.42
248.23	2.57	2.57
281.77	3.00	3.00
277.35	2.41	2.41
292.36	2.97	2.97
234.33	2.11	2.11