Basic Information
ID: ALA4121210
Type: Binding
Description: Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 20 mins in presence of NAD+ by resazurin fluorescence based PSAT1/diaphorase/PSPH coupled enzyme assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4121210
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 380.44 | 3.93 | 3.93 |
| 430.50 | 5.08 | 5.08 |
| 394.47 | 4.24 | 4.24 |
| 327.46 | 2.61 | 2.61 |
| 424.45 | 3.41 | 3.41 |
| 379.45 | 4.10 | 4.10 |
| 363.39 | 3.58 | 3.58 |
| 395.45 | 3.63 | 3.63 |
| 395.45 | 3.63 | 3.63 |
| 381.43 | 3.32 | 3.32 |
| 366.41 | 3.62 | 3.62 |
| 408.49 | 4.23 | 4.23 |
| 394.47 | 3.95 | 3.95 |
| 434.41 | 4.64 | 4.64 |
| 416.47 | 4.77 | 4.77 |
| 365.42 | 3.91 | 3.91 |
| 379.45 | 4.53 | 4.53 |
| 366.41 | 3.62 | 3.62 |
| 364.37 | 3.76 | 3.76 |
| 366.41 | 3.62 | 3.62 |
| 327.46 | 2.61 | 2.61 |
| 408.49 | 4.23 | 4.23 |
| 438.52 | 3.59 | 3.59 |
| 436.50 | 4.31 | 4.31 |
| 340.50 | 3.21 | 3.21 |
| 408.49 | 4.23 | 4.23 |
| 436.50 | 4.31 | 4.31 |
| 408.49 | 4.99 | 4.99 |
| 370.52 | 3.22 | 3.22 |
| 382.45 | 3.79 | 3.79 |
| 370.52 | 3.22 | 3.22 |
| 434.53 | 4.48 | 4.48 |
| 356.50 | 3.23 | 3.23 |
| 422.52 | 4.62 | 4.62 |
| 422.52 | 4.62 | 4.62 |
| 354.52 | 3.52 | 3.52 |
| 396.48 | 4.14 | 4.14 |
| 341.48 | 2.61 | 2.61 |
| 408.49 | 4.99 | 4.99 |
| 452.50 | 3.69 | 3.69 |
| 422.52 | 4.67 | 4.67 |
| 422.52 | 4.62 | 4.62 |
| 422.48 | 3.87 | 3.87 |
| 374.94 | 3.87 | 3.87 |
| 374.94 | 3.87 | 3.87 |
| 394.47 | 4.24 | 4.24 |
| 370.52 | 3.22 | 3.22 |
| 327.46 | 2.61 | 2.61 |
| 484.59 | 5.97 | 5.97 |
| 422.52 | 4.27 | 4.27 |
| 341.48 | 2.61 | 2.61 |
| 436.50 | 4.31 | 4.31 |
| 354.52 | 3.52 | 3.52 |
| 408.49 | 4.99 | 4.99 |
| 358.49 | 3.35 | 3.35 |
| 422.48 | 3.87 | 3.87 |
| 374.94 | 3.87 | 3.87 |
| 424.49 | 4.11 | 4.11 |
| 380.44 | 3.30 | 3.30 |
| 422.52 | 4.62 | 4.62 |
| 422.52 | 4.79 | 4.79 |
| 408.49 | 4.99 | 4.99 |
| 410.51 | 4.48 | 4.48 |
| 422.52 | 4.67 | 4.67 |
| 358.49 | 3.35 | 3.35 |
| 436.50 | 4.31 | 4.31 |
| 356.50 | 3.23 | 3.23 |
| 394.47 | 4.24 | 4.24 |
| 356.50 | 3.23 | 3.23 |
| 436.55 | 5.01 | 5.01 |
| 358.49 | 3.35 | 3.35 |
| 354.52 | 3.52 | 3.52 |
| 419.39 | 3.98 | 3.98 |
| 341.48 | 2.61 | 2.61 |