Basic Information
ID: ALA4121350
Type: Binding
Description: Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated transcriptional activity after 24 hrs by dual glo luciferase reporter gene assay relative to T0901317
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4121350
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 643.90 | 5.81 | 5.81 |
| 596.22 | 5.95 | 5.95 |
| 598.84 | 5.22 | 5.22 |
| 569.79 | 6.07 | 6.07 |
| 614.47 | 5.65 | 5.65 |
| 485.68 | 5.26 | 5.26 |
| 568.16 | 5.26 | 5.26 |
| 558.77 | 5.06 | 5.06 |
| 584.76 | 5.15 | 5.15 |
| 628.50 | 5.58 | 5.58 |
| 587.81 | 5.48 | 5.48 |
| 551.75 | 6.11 | 6.11 |
| 620.66 | 7.14 | 7.14 |
| 603.83 | 4.94 | 4.94 |
| 584.81 | 5.40 | 5.40 |
| 615.79 | 6.10 | 6.10 |
| 623.72 | 5.91 | 5.91 |
| 613.80 | 5.12 | 5.12 |
| 592.17 | 6.10 | 6.10 |
| 595.79 | 5.90 | 5.90 |
| 602.53 | 5.89 | 5.89 |
| 593.71 | 6.50 | 6.50 |
| 646.56 | 4.56 | 4.56 |
| 577.79 | 4.64 | 4.64 |
| 591.70 | 6.26 | 6.26 |
| 555.64 | 4.65 | 4.65 |
| 566.75 | 4.92 | 4.92 |
| 589.81 | 4.69 | 4.69 |
| 629.77 | 6.05 | 6.05 |
| 597.80 | 6.15 | 6.15 |
| 601.71 | 5.62 | 5.62 |
| 604.14 | 5.80 | 5.80 |
| 583.78 | 5.76 | 5.76 |
| 597.80 | 6.10 | 6.10 |
| 615.72 | 4.45 | 4.45 |
| 611.83 | 6.35 | 6.35 |
| 557.78 | 5.66 | 5.66 |
| 569.62 | 4.82 | 4.82 |
| 602.68 | 5.76 | 5.76 |
| 606.52 | 5.16 | 5.16 |
| 634.67 | 5.19 | 5.19 |
| 615.84 | 5.03 | 5.03 |
| 595.67 | 5.13 | 5.13 |
| 602.61 | 5.91 | 5.91 |
| 605.72 | 6.65 | 6.65 |
| 508.73 | 6.87 | 6.87 |
| 613.75 | 5.51 | 5.51 |
| 605.65 | 5.28 | 5.28 |
| 667.92 | 6.89 | 6.89 |