Basic Information
ID: ALA4121352
Type: Binding
Description: Inverse agonist activity at human GAL4 DBD-fused RORbeta LBD (201 to 452 residues) expressed in HEK293T cells assessed as reduction in ROR mediated transcriptional activity after 24 hrs by dual glo luciferase reporter gene assay relative to N-[5-(2-chloro-benzoyl)-4-(3-chlorophenyl)-thiazol-2-yl]-2-(4-ethanesulfonyl-phenyl)-acetamide
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4121352
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 596.22 | 5.95 | 5.95 |
| 628.50 | 5.58 | 5.58 |
| 587.81 | 5.48 | 5.48 |
| 551.75 | 6.11 | 6.11 |
| 620.66 | 7.14 | 7.14 |
| 623.72 | 5.91 | 5.91 |
| 593.71 | 6.50 | 6.50 |
| 591.70 | 6.26 | 6.26 |
| 566.75 | 4.92 | 4.92 |
| 629.77 | 6.05 | 6.05 |
| 583.78 | 5.76 | 5.76 |
| 602.68 | 5.76 | 5.76 |
| 595.67 | 5.13 | 5.13 |
| 605.72 | 6.65 | 6.65 |
| 613.75 | 5.51 | 5.51 |
| 605.65 | 5.28 | 5.28 |
| 667.92 | 6.89 | 6.89 |