Activation of MEK1/2 in EGF-stimulated human MDA-MB-231 cells assessed as increase in pERK1/2 levels preincubated for 30 mins followed by EGF stimulat...

Basic Information

ID: ALA4124007

Type: ADME

Description: Activation of MEK1/2 in EGF-stimulated human MDA-MB-231 cells assessed as increase in pERK1/2 levels preincubated for 30 mins followed by EGF stimulation measured after 15 mins by Western blot analysis relative to control

Format: BAO_0000219

Organism: Homo sapiens

Cell type: MDA-MB-231

Target:  Dual specificity mitogen-activated protein kinase kinase; MEK1/2(ALA2111289)

Document:  ALA4118214

Activation of MEK1/2 in EGF-stimulated human MDA-MB-231 cells assessed as increase in pERK1/2 levels preincubated for 30 mins followed by EGF stimulation measured after 15 mins by Western blot analysis relative to control: 1

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
489.283.863.86
230.242.672.67
331.373.103.10