Basic Information
ID: ALA4124671
Type: Binding
Description: Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 2 uM preincubated for 1 hr with 100 nM pan-HDAC inhibitor N-hydroxy-8-(2-(4-methoxybenzylidene)hydrazinyl)-8-oxooctanamide followed by compound addition for 12 hrs by immunoblotting analysis
Organism: Homo sapiens
Cell type: MCF7
Activity Charts
Bioactivity
Activity Types for Assay ALA4124671
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 775.82 | 1.70 | 1.70 |