Basic Information
ID: ALA4125669
Type: Binding
Description: Inhibition of nigericin-induced NLRP3 inflammasome activation in PMA-differentiated human THP1 cells assessed as reduction in LPS-stimulated IL-1beta secretion incubated for 1 hr prior to stimulation with nigericin for 1 hr by quanti-blue based SEAP reporter gene assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4125669
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 144.10 | 0.16 | 0.16 |
| 188.15 | 0.37 | 0.37 |
| 126.11 | -0.13 | -0.13 |
| 146.14 | -1.30 | -1.30 |
| 128.13 | -0.50 | -0.50 |
| 198.22 | 0.85 | 0.85 |
| 170.16 | 0.07 | 0.07 |
| 254.33 | 2.41 | 2.41 |
| 230.19 | 0.69 | 0.69 |