Basic Information
ID: ALA4132673
Type: Binding
Description: Inhibition of recombinant mouse N-terminal FLAG-tagged Notch1 (1704 to 2531 residues) expressed in human LS174T cells assessed as reduction in doxycycline-induced NICD expression after 12 hrs by Bright-Glo luciferase reporter gene assay
Organism: Homo sapiens
Cell type: LS174T
Activity Charts
Bioactivity
Activity Types for Assay ALA4132673
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 589.75 | 2.67 | 2.67 |
| 532.63 | 2.00 | 2.00 |
| 530.61 | 2.21 | 2.21 |
| 574.67 | 2.57 | 2.57 |
| 587.74 | 3.15 | 3.15 |
| 603.73 | 2.20 | 2.20 |
| 603.73 | 2.12 | 2.12 |
| 578.66 | 0.79 | 0.79 |