Basic Information
ID: ALA4132839
Type: Binding
Description: Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of leucovorin by MTT assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Thymidylate synthase/GAR transformylase/AICAR transformylase(ALA3885528)
Document: ALA4130394
Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of leucovorin by MTT assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4132839
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.45 | 0.27 | 0.27 |
| 427.42 | 0.67 | 0.67 |
| 450.45 | -0.51 | -0.51 |
| 408.37 | -1.68 | -1.68 |
| 422.40 | -1.29 | -1.29 |
| 456.42 | 0.06 | 0.06 |
| 436.43 | -0.90 | -0.90 |
| 394.34 | -2.07 | -2.07 |