Basic Information
ID: ALA4133035
Type: Binding
Description: Inhibition of recombinant human 15-LOX-1 expressed in Escherichia coli BL21(DE3) assessed as residual activity at 50 uM using linoleic acid as substrate preincubated for 10 mins followed by substrate addition
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4133035
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 395.42 | 2.62 | 2.62 |
| 527.42 | 5.71 | 5.71 |
| 431.92 | 5.93 | 5.93 |
| 321.77 | 4.02 | 4.02 |
| 426.47 | 4.74 | 4.74 |
| 517.42 | 6.26 | 6.26 |
| 384.23 | 3.36 | 3.36 |
| 505.37 | 5.51 | 5.51 |
| 481.45 | 5.58 | 5.58 |
| 399.24 | 4.04 | 4.04 |
| 366.22 | 4.13 | 4.13 |
| 538.45 | 6.90 | 6.90 |
| 446.51 | 4.97 | 4.97 |
| 518.41 | 5.24 | 5.24 |
| 550.46 | 6.85 | 6.85 |
| 382.41 | 5.00 | 5.00 |
| 479.37 | 5.17 | 5.17 |
| 449.51 | 4.34 | 4.34 |
| 455.51 | 4.44 | 4.44 |
| 516.52 | 5.97 | 5.97 |
| 365.39 | 2.61 | 2.61 |
| 493.52 | 4.86 | 4.86 |
| 429.91 | 5.08 | 5.08 |
| 482.97 | 5.60 | 5.60 |
| 471.29 | 6.31 | 6.31 |
| 513.00 | 5.61 | 5.61 |
| 380.88 | 5.38 | 5.38 |
| 606.32 | 6.47 | 6.47 |
| 538.60 | 4.97 | 4.97 |
| 353.35 | 2.74 | 2.74 |
| 466.52 | 5.09 | 5.09 |
| 440.45 | 5.81 | 5.81 |
| 527.42 | 5.71 | 5.71 |
| 346.39 | 2.78 | 2.78 |
| 400.87 | 5.38 | 5.38 |
| 451.35 | 5.55 | 5.55 |
| 405.45 | 3.40 | 3.40 |
| 399.24 | 4.04 | 4.04 |
| 557.28 | 6.54 | 6.54 |
| 530.99 | 5.75 | 5.75 |
| 532.35 | 6.75 | 6.75 |
| 425.33 | 5.49 | 5.49 |
| 466.38 | 5.32 | 5.32 |
| 388.47 | 3.95 | 3.95 |
| 504.20 | 7.34 | 7.34 |
| 425.33 | 5.49 | 5.49 |
| 354.79 | 3.93 | 3.93 |
| 557.45 | 5.72 | 5.72 |
| 415.32 | 6.03 | 6.03 |
| 524.21 | 6.25 | 6.25 |
| 414.43 | 5.74 | 5.74 |
| 445.52 | 5.58 | 5.58 |
| 430.90 | 4.47 | 4.47 |
| 528.41 | 5.11 | 5.11 |
| 364.42 | 4.86 | 4.86 |
| 514.21 | 6.80 | 6.80 |
| 483.52 | 5.55 | 5.55 |
| 516.52 | 5.97 | 5.97 |
| 419.87 | 4.67 | 4.67 |
| 351.36 | 2.31 | 2.31 |
| 398.44 | 5.06 | 5.06 |
| 447.97 | 5.77 | 5.77 |
| 546.55 | 5.98 | 5.98 |
| 463.51 | 5.72 | 5.72 |
| 500.96 | 5.74 | 5.74 |
| 514.41 | 6.88 | 6.88 |
| 348.41 | 2.66 | 2.66 |
| 493.52 | 4.86 | 4.86 |
| 439.90 | 5.86 | 5.86 |
| 466.38 | 5.32 | 5.32 |
| 511.42 | 3.71 | 3.71 |
| 366.22 | 4.13 | 4.13 |
| 521.62 | 7.25 | 7.25 |
| 577.48 | 6.86 | 6.86 |
| 596.31 | 7.02 | 7.02 |
| 448.48 | 3.25 | 3.25 |
| 497.39 | 3.01 | 3.01 |
| 367.41 | 4.12 | 4.12 |
| 414.89 | 5.69 | 5.69 |
| 590.42 | 6.63 | 6.63 |
| 505.57 | 5.60 | 5.60 |
| 533.22 | 4.49 | 4.49 |
| 449.51 | 4.34 | 4.34 |
| 348.23 | 4.03 | 4.03 |
| 384.23 | 3.36 | 3.36 |
| 427.91 | 5.13 | 5.13 |
| 393.87 | 4.38 | 4.38 |
| 355.40 | 3.75 | 3.75 |
| 445.32 | 5.49 | 5.49 |
| 437.54 | 5.71 | 5.71 |
| 464.53 | 4.65 | 4.65 |
| 348.23 | 4.03 | 4.03 |
| 456.50 | 4.75 | 4.75 |
| 659.51 | 9.45 | 9.45 |
| 485.34 | 5.36 | 5.36 |
| 441.96 | 3.85 | 3.85 |
| 423.45 | 5.35 | 5.35 |
| 381.39 | 2.32 | 2.32 |
| 306.33 | 1.99 | 1.99 |
| 373.33 | 3.61 | 3.61 |
| 424.44 | 4.74 | 4.74 |
| 531.62 | 8.03 | 8.03 |
| 521.21 | 4.40 | 4.40 |
| 457.89 | 6.00 | 6.00 |
| 571.24 | 6.09 | 6.09 |
| 629.35 | 7.62 | 7.62 |
| 577.28 | 7.04 | 7.04 |
| 351.30 | 3.84 | 3.84 |
| 478.55 | 4.96 | 4.96 |
| 513.52 | 6.60 | 6.60 |
| 395.48 | 3.17 | 3.17 |
| 465.51 | 5.22 | 5.22 |
| 528.41 | 5.11 | 5.11 |
| 561.87 | 6.36 | 6.36 |
| 406.45 | 4.60 | 4.60 |
| 516.52 | 5.97 | 5.97 |
| 517.42 | 6.26 | 6.26 |
| 496.54 | 5.10 | 5.10 |
| 339.78 | 3.25 | 3.25 |
| 462.55 | 5.26 | 5.26 |
| 349.35 | 2.32 | 2.32 |
| 445.32 | 5.49 | 5.49 |
| 493.99 | 6.27 | 6.27 |
| 424.30 | 4.15 | 4.15 |
| 446.30 | 4.88 | 4.88 |
| 587.47 | 5.73 | 5.73 |
| 545.41 | 5.85 | 5.85 |
| 481.50 | 5.86 | 5.86 |
| 587.30 | 6.55 | 6.55 |
| 527.42 | 5.71 | 5.71 |
| 374.23 | 3.90 | 3.90 |
| 395.46 | 4.54 | 4.54 |
| 482.41 | 6.42 | 6.42 |
| 548.28 | 4.70 | 4.70 |
| 382.85 | 3.25 | 3.25 |
| 572.89 | 7.56 | 7.56 |
| 395.89 | 4.68 | 4.68 |
| 491.51 | 6.31 | 6.31 |
| 513.52 | 6.60 | 6.60 |
| 422.51 | 5.94 | 5.94 |
| 306.33 | 1.99 | 1.99 |
| 476.58 | 5.57 | 5.57 |
| 547.44 | 6.26 | 6.26 |
| 306.33 | 1.99 | 1.99 |
| 215.26 | 1.64 | 1.64 |
| 482.58 | 4.54 | 4.54 |
| 503.19 | 4.91 | 4.91 |
| 451.53 | 4.40 | 4.40 |
| 485.79 | 6.20 | 6.20 |
| 325.33 | 3.83 | 3.83 |
| 546.47 | 6.48 | 6.48 |
| 305.34 | 2.59 | 2.59 |
| 522.40 | 4.80 | 4.80 |
| 391.43 | 4.63 | 4.63 |
| 435.31 | 6.03 | 6.03 |
| 577.69 | 7.15 | 7.15 |
| 473.45 | 6.23 | 6.23 |
| 346.43 | 4.72 | 4.72 |
| 606.32 | 6.47 | 6.47 |
| 500.96 | 5.74 | 5.74 |
| 405.50 | 4.51 | 4.51 |
| 483.50 | 5.36 | 5.36 |
| 577.48 | 6.86 | 6.86 |
| 495.58 | 6.73 | 6.73 |
| 547.44 | 6.26 | 6.26 |
| 451.35 | 5.55 | 5.55 |
| 561.87 | 6.36 | 6.36 |
| 462.55 | 5.26 | 5.26 |
| 453.93 | 6.17 | 6.17 |
| 527.97 | 5.51 | 5.51 |
| 416.48 | 5.88 | 5.88 |
| 531.25 | 5.65 | 5.65 |
| 443.93 | 5.39 | 5.39 |
| 518.80 | 6.62 | 6.62 |
| 435.31 | 6.03 | 6.03 |
| 603.31 | 7.10 | 7.10 |
| 448.53 | 4.95 | 4.95 |
| 536.79 | 6.76 | 6.76 |
| 482.97 | 5.60 | 5.60 |
| 455.48 | 5.58 | 5.58 |
| 279.73 | 1.88 | 1.88 |
| 545.41 | 5.85 | 5.85 |
| 630.54 | 8.02 | 8.02 |
| 416.45 | 3.77 | 3.77 |
| 596.31 | 7.02 | 7.02 |
| 495.38 | 6.64 | 6.64 |
| 457.89 | 6.00 | 6.00 |
| 492.54 | 4.68 | 4.68 |
| 355.40 | 3.75 | 3.75 |
| 563.40 | 5.99 | 5.99 |
| 545.27 | 6.08 | 6.08 |
| 571.43 | 5.44 | 5.44 |
| 473.45 | 6.23 | 6.23 |
| 492.41 | 6.60 | 6.60 |
| 561.87 | 6.36 | 6.36 |
| 536.86 | 6.46 | 6.46 |
| 508.41 | 5.78 | 5.78 |
| 465.51 | 5.22 | 5.22 |