Basic Information
ID: ALA4133147
Type: Binding
Description: Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake at 10 uM preincubated for 10 mins followed by ATP addition measured after 20 mins by FLIPR assay relative to 1 mM ATP
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4133147
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 175.19 | 0.76 | 0.76 |
| 209.64 | 1.41 | 1.41 |
| 313.74 | 3.28 | 3.28 |
| 205.22 | 0.77 | 0.77 |
| 244.08 | 2.07 | 2.07 |
| 244.08 | 2.07 | 2.07 |
| 173.17 | 1.08 | 1.08 |
| 203.20 | 1.09 | 1.09 |
| 242.06 | 2.39 | 2.39 |
| 188.19 | 1.08 | 1.08 |
| 309.33 | 2.63 | 2.63 |
| 173.18 | 1.08 | 1.08 |
| 363.89 | 5.10 | 5.10 |
| 203.25 | 1.80 | 1.80 |
| 188.19 | 1.08 | 1.08 |
| 237.69 | 2.46 | 2.46 |
| 286.12 | 2.64 | 2.64 |
| 272.13 | 3.11 | 3.11 |
| 273.34 | 2.89 | 2.89 |
| 247.30 | 2.20 | 2.20 |
| 329.44 | 4.45 | 4.45 |
| 265.74 | 3.24 | 3.24 |
| 329.44 | 4.45 | 4.45 |
| 279.30 | 2.62 | 2.62 |
| 300.19 | 3.89 | 3.89 |
| 233.27 | 1.81 | 1.81 |
| 301.35 | 2.51 | 2.51 |
| 251.67 | 1.98 | 1.98 |
| 231.30 | 2.58 | 2.58 |
| 217.27 | 2.19 | 2.19 |
| 247.25 | 1.34 | 1.34 |
| 340.21 | 3.81 | 3.81 |
| 279.30 | 2.62 | 2.62 |
| 203.24 | 1.80 | 1.80 |
| 261.32 | 2.59 | 2.59 |
| 251.72 | 2.85 | 2.85 |
| 348.19 | 3.93 | 3.93 |
| 398.33 | 5.76 | 5.76 |
| 307.78 | 3.54 | 3.54 |
| 286.16 | 3.50 | 3.50 |
| 217.23 | 1.33 | 1.33 |
| 286.16 | 3.50 | 3.50 |
| 348.19 | 3.93 | 3.93 |
| 286.12 | 2.64 | 2.64 |
| 217.23 | 1.33 | 1.33 |
| 257.08 | 2.38 | 2.38 |
| 175.19 | 0.76 | 0.76 |
| 271.32 | 2.50 | 2.50 |
| 231.30 | 2.58 | 2.58 |
| 217.27 | 2.19 | 2.19 |
| 272.13 | 3.11 | 3.11 |