Basic Information
ID: ALA4135330
Type: Binding
Description: Inhibition of TSPO in mouse HT22 cells assessed as reduction in amyloid beta (1 to 42) (unknown origin) induced mitochondrial permeability transition pore formation by measuring increase in green to red fluorescence ratio at 5 uM pretreated for 10 mins followed by amyloid beta (1 to 42) stimulation and measured at 1 hr interval for 3 hrs by JC-1 dye based fluorescence assay relative to control
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA4135330
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 319.19 | 3.81 | 3.81 |
| 1202.63 | ||
| 329.20 | 3.26 | 3.26 |
| 382.51 | 4.26 | 4.26 |
| 410.85 | 4.85 | 4.85 |
| 276.36 | 2.18 | 2.18 |
| 264.33 | 2.81 | 2.81 |
| 426.54 | 3.77 | 3.77 |
| 442.57 | 4.56 | 4.56 |
| 396.54 | 4.39 | 4.39 |
| 462.98 | 4.91 | 4.91 |
| 451.62 | 4.26 | 4.26 |
| 414.51 | 4.00 | 4.00 |
| 368.46 | 3.23 | 3.23 |
| 306.39 | 2.25 | 2.25 |
| 327.86 | 3.93 | 3.93 |
| 410.54 | 4.07 | 4.07 |
| 416.96 | 4.91 | 4.91 |
| 382.51 | 4.32 | 4.32 |
| 410.57 | 4.65 | 4.65 |
| 421.53 | 2.62 | 2.62 |
| 437.59 | 3.95 | 3.95 |
| 363.41 | 3.62 | 3.62 |
| 365.82 | 4.71 | 4.71 |
| 378.46 | 3.64 | 3.64 |
| 394.50 | 3.38 | 3.38 |
| 366.45 | 2.99 | 2.99 |
| 359.41 | 2.95 | 2.95 |
| 304.38 | 1.42 | 1.42 |
| 382.51 | 3.97 | 3.97 |
| 428.54 | 4.25 | 4.25 |
| 382.51 | 4.55 | 4.55 |
| 424.60 | 4.96 | 4.96 |
| 437.59 | 4.00 | 4.00 |
| 304.38 | 1.36 | 1.36 |
| 305.33 | 4.04 | 4.04 |
| 354.46 | 3.98 | 3.98 |
| 310.42 | 3.73 | 3.73 |
| 348.45 | 3.02 | 3.02 |
| 412.47 | 2.93 | 2.93 |
| 392.57 | 5.29 | 5.29 |
| 368.49 | 3.66 | 3.66 |
| 472.04 | 4.60 | 4.60 |
| 328.46 | 3.67 | 3.67 |
| 368.49 | 4.01 | 4.01 |
| 394.50 | 3.32 | 3.32 |
| 308.31 | 1.67 | 1.67 |
| 402.93 | 4.89 | 4.89 |
| 324.45 | 3.99 | 3.99 |
| 412.47 | 2.98 | 2.98 |
| 423.57 | 3.69 | 3.69 |
| 382.51 | 3.91 | 3.91 |
| 396.54 | 4.57 | 4.57 |
| 310.81 | 3.41 | 3.41 |
| 397.29 | 2.70 | 2.70 |
| 366.45 | 2.94 | 2.94 |
| 396.54 | 4.22 | 4.22 |
| 410.57 | 4.70 | 4.70 |
| 325.36 | 2.83 | 2.83 |
| 342.42 | 3.36 | 3.36 |
| 368.49 | 4.29 | 4.29 |
| 368.49 | 4.24 | 4.24 |
| 361.46 | 3.49 | 3.49 |