Basic Information
ID: ALA4137131
Type: Binding
Description: Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS complex formation by measuring exchange of GTP to BODIPY-GDP measured every 3 secs for 30 mins by fluorescence polarization assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4137131
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 445.57 | 3.31 | 3.31 |
| 480.01 | 3.96 | 3.96 |
| 484.43 | 4.61 | 4.61 |
| 476.02 | 4.30 | 4.30 |
| 287.36 | 1.24 | 1.24 |
| 464.01 | 4.26 | 4.26 |
| 449.99 | 3.95 | 3.95 |
| 476.02 | 4.07 | 4.07 |
| 494.44 | 4.06 | 4.06 |
| 462.00 | 3.91 | 3.91 |
| 496.44 | 4.42 | 4.42 |
| 429.57 | 3.61 | 3.61 |
| 333.44 | 3.56 | 3.56 |
| 386.50 | 3.97 | 3.97 |
| 449.99 | 3.95 | 3.95 |
| 285.39 | 2.66 | 2.66 |
| 429.57 | 3.61 | 3.61 |
| 480.01 | 3.96 | 3.96 |
| 484.43 | 4.61 | 4.61 |
| 510.47 | 5.09 | 5.09 |
| 476.02 | 4.30 | 4.30 |
| 361.49 | 3.88 | 3.88 |
| 400.53 | 4.36 | 4.36 |
| 286.38 | 1.21 | 1.21 |
| 476.02 | 4.44 | 4.44 |
| 483.54 | 4.32 | 4.32 |
| 464.01 | 4.20 | 4.20 |
| 449.99 | 3.95 | 3.95 |
| 462.00 | 3.76 | 3.76 |
| 490.05 | 4.75 | 4.75 |
| 415.54 | 3.30 | 3.30 |
| 517.98 | 4.97 | 4.97 |
| 334.42 | 2.96 | 2.96 |
| 449.99 | 3.95 | 3.95 |
| 433.53 | 3.44 | 3.44 |
| 517.98 | 4.97 | 4.97 |
| 464.01 | 4.26 | 4.26 |
| 362.48 | 3.28 | 3.28 |
| 229.33 | 2.09 | 2.09 |
| 416.53 | 2.69 | 2.69 |
| 415.54 | 3.30 | 3.30 |