Basic Information
ID: ALA4143728
Type: Binding
Description: Inhibition of NAE in human Caco2 cells assessed as increase in p53 protein levels by measuring p53 degradation at 10 uM preincubated for 16 hrs followed by cycloheximide addition measured up to 60 mins by Western blot analysis relative to control
Format: BAO_0000219
Organism: Homo sapiens
Target: NEDD8 activating enzyme(ALA3831283)
Document: ALA4138244
Inhibition of NAE in human Caco2 cells assessed as increase in p53 protein levels by measuring p53 degradation at 10 uM preincubated for 16 hrs followed by cycloheximide addition measured up to 60 mins by Western blot analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4143728
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 444.49 | -0.14 | -0.14 |