Antagonist activity at mAChR in human CCRF-CEM cells assessed as inhibition of acetylcholine-stimulated Ca2+ flux pretreated for 25 mins followed by a...

Basic Information

ID: ALA4144311

Type: ADME

Description: Antagonist activity at mAChR in human CCRF-CEM cells assessed as inhibition of acetylcholine-stimulated Ca2+ flux pretreated for 25 mins followed by acetylacholine addition measured for 90 secs by calcium dye-based fluorescence assay

Format: BAO_0000219

Organism: Homo sapiens

Cell type: CCRF-CEM

Target: Muscarinic acetylcholine receptor(ALA2094109)

Document: ALA4138267

Antagonist activity at mAChR in human CCRF-CEM cells assessed as inhibition of acetylcholine-stimulated Ca2+ flux pretreated for 25 mins followed by acetylacholine addition measured for 90 secs by calcium dye-based fluorescence assay: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4144311

IC50

Total(28)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
364.54	3.21	3.21
352.53	3.21	3.21
354.50	2.35	2.35
342.46	2.48	2.48
374.53	3.49	3.49
356.49	2.78	2.78
358.92	2.99	2.99
392.47	3.36	3.36
378.56	3.52	3.52
358.92	2.99	2.99
352.53	3.21	3.21
338.50	2.65	2.65
364.54	3.21	3.21
338.50	2.90	2.90
338.50	2.65	2.65
342.46	2.48	2.48
352.53	2.95	2.95
354.50	2.35	2.35
366.51	2.66	2.66
374.53	3.49	3.49
358.92	2.99	2.99
356.49	2.78	2.78
338.50	2.65	2.65
392.47	3.36	3.36
324.47	2.34	2.34
338.50	2.65	2.65
374.53	3.49	3.49
350.51	2.98	2.98