Basic Information
ID: ALA4146144
Type: Binding
Description: Corrector activity at CFTR F508-del mutant (unknown origin) expressed in human CFBE41o cells harboring HS-YFP preincubated for 24 hrs followed by forskolin/genistein stimulation for 30 mins by fluorescence assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Cystic fibrosis transmembrane conductance regulator(ALA4051)
Document: ALA4145449
Corrector activity at CFTR F508-del mutant (unknown origin) expressed in human CFBE41o cells harboring HS-YFP preincubated for 24 hrs followed by forskolin/genistein stimulation for 30 mins by fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4146144
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 456.98 | 6.23 | 6.23 |
| 436.99 | 5.97 | 5.97 |
| 568.50 | 6.31 | 6.31 |
| 510.66 | 4.42 | 4.42 |
| 374.44 | 3.57 | 3.57 |
| 388.47 | 3.96 | 3.96 |
| 400.48 | 3.69 | 3.69 |
| 400.48 | 3.69 | 3.69 |
| 374.44 | 3.57 | 3.57 |
| 374.44 | 3.57 | 3.57 |
| 345.41 | 2.96 | 2.96 |
| 345.41 | 2.96 | 2.96 |
| 345.41 | 2.96 | 2.96 |
| 344.42 | 3.57 | 3.57 |
| 404.47 | 3.58 | 3.58 |
| 404.47 | 3.58 | 3.58 |
| 346.39 | 2.36 | 2.36 |
| 375.43 | 2.97 | 2.97 |
| 404.47 | 3.58 | 3.58 |
| 400.48 | 3.69 | 3.69 |
| 371.44 | 3.08 | 3.08 |
| 371.44 | 3.08 | 3.08 |
| 371.44 | 3.08 | 3.08 |
| 388.47 | 3.96 | 3.96 |
| 388.47 | 3.96 | 3.96 |
| 359.43 | 3.35 | 3.35 |
| 359.43 | 3.35 | 3.35 |
| 359.43 | 3.35 | 3.35 |
| 452.41 | 4.75 | 4.75 |
| 401.51 | 3.06 | 3.06 |
| 428.54 | 2.80 | 2.80 |
| 443.56 | 1.70 | 1.70 |
| 457.63 | 3.15 | 3.15 |
| 457.63 | 2.78 | 2.78 |
| 428.54 | 2.80 | 2.80 |
| 443.56 | 1.70 | 1.70 |
| 457.63 | 3.15 | 3.15 |
| 457.63 | 2.78 | 2.78 |
| 457.63 | 3.15 | 3.15 |
| 457.63 | 2.78 | 2.78 |
| 487.65 | 2.79 | 2.79 |
| 475.62 | 2.92 | 2.92 |
| 460.58 | 2.22 | 2.22 |
| 458.57 | 2.81 | 2.81 |
| 455.57 | 3.80 | 3.80 |
| 473.58 | 1.71 | 1.71 |
| 463.66 | 2.84 | 2.84 |
| 499.71 | 3.90 | 3.90 |
| 463.67 | 3.16 | 3.16 |
| 471.61 | 2.42 | 2.42 |
| 507.66 | 1.97 | 1.97 |
| 486.62 | 3.55 | 3.55 |
| 491.04 | 4.20 | 4.20 |
| 477.01 | 3.86 | 3.86 |
| 490.32 | 4.81 | 4.81 |
| 470.93 | 5.04 | 5.04 |
| 344.39 | 3.05 | 3.05 |
| 532.07 | 4.85 | 4.85 |
| 493.33 | 5.87 | 5.87 |
| 380.43 | 3.91 | 3.91 |
| 378.45 | 4.52 | 4.52 |
| 422.46 | 4.22 | 4.22 |
| 412.90 | 5.17 | 5.17 |
| 487.63 | 5.65 | 5.65 |
| 416.41 | 4.51 | 4.51 |
| 382.42 | 4.35 | 4.35 |
| 468.53 | 5.44 | 5.44 |
| 398.87 | 4.86 | 4.86 |
| 412.90 | 5.17 | 5.17 |
| 453.57 | 5.12 | 5.12 |
| 434.85 | 5.46 | 5.46 |
| 398.87 | 4.86 | 4.86 |
| 408.44 | 3.91 | 3.91 |
| 568.10 | 6.64 | 6.64 |
| 448.88 | 5.76 | 5.76 |
| 396.44 | 4.66 | 4.66 |
| 515.39 | 5.15 | 5.15 |
| 426.54 | 4.90 | 4.90 |
| 332.36 | 3.63 | 3.63 |
| 506.03 | 4.10 | 4.10 |
| 394.45 | 4.22 | 4.22 |
| 423.54 | 5.11 | 5.11 |
| 416.41 | 4.51 | 4.51 |
| 434.52 | 3.17 | 3.17 |
| 446.57 | 4.13 | 4.13 |
| 421.48 | 4.17 | 4.17 |
| 443.32 | 4.97 | 4.97 |
| 470.93 | 5.04 | 5.04 |
| 380.43 | 3.91 | 3.91 |
| 327.41 | 3.81 | 3.81 |
| 394.45 | 4.22 | 4.22 |
| 457.35 | 5.28 | 5.28 |