Basic Information
ID: ALA4146976
Type: Functional
Description: Antagonist activity at human GnRH receptor expressed in HEK293 cells co-expressing pGL4-NFATpromoter AP-1-luc assessed as inhibition of GnRH-induced NFAT promoter activation preincubated for 1 hr followed by GnRH addition measured after 6 hrs by luciferase reporter gene assay
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4146976
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 577.63 | 4.82 | 4.82 |
| 606.63 | 3.28 | 3.28 |
| 633.62 | 4.29 | 4.29 |
| 737.70 | 4.92 | 4.92 |
| 604.66 | 3.88 | 3.88 |
| 638.65 | 3.72 | 3.72 |
| 619.59 | 3.98 | 3.98 |
| 608.62 | 3.71 | 3.71 |
| 651.61 | 4.43 | 4.43 |
| 622.65 | 4.02 | 4.02 |
| 721.70 | 5.22 | 5.22 |
| 608.62 | 3.71 | 3.71 |
| 608.62 | 3.71 | 3.71 |
| 603.59 | 4.28 | 4.28 |
| 685.72 | 4.94 | 4.94 |
| 719.71 | 4.78 | 4.78 |
| 590.63 | 3.58 | 3.58 |
| 620.66 | 3.58 | 3.58 |
| 604.66 | 3.88 | 3.88 |
| 635.61 | 4.73 | 4.73 |