Basic Information
ID: ALA4150900
Type: ADME
Description: Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4150900
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 323.22 | 3.47 | 3.47 |
| 318.63 | 1.45 | 1.45 |
| 329.25 | 3.53 | 3.53 |
| 255.15 | 1.54 | 1.54 |
| 313.18 | 3.06 | 3.06 |
| 356.08 | 0.85 | 0.85 |
| 291.25 | 2.83 | 2.83 |
| 219.12 | 0.70 | 0.70 |
| 277.15 | 1.81 | 1.81 |
| 271.15 | 1.65 | 1.65 |
| 281.19 | 2.06 | 2.06 |
| 376.74 | 3.33 | 3.33 |
| 219.12 | 0.70 | 0.70 |
| 414.19 | 2.73 | 2.73 |
| 305.27 | 3.22 | 3.22 |
| 360.67 | 2.86 | 2.86 |
| 235.11 | 0.40 | 0.40 |
| 398.12 | 2.26 | 2.26 |
| 329.25 | 3.53 | 3.53 |
| 242.54 | -0.21 | -0.21 |
| 313.18 | 3.06 | 3.06 |
| 289.21 | 2.75 | 2.75 |
| 318.63 | 1.45 | 1.45 |
| 205.09 | 0.39 | 0.39 |
| 247.17 | 1.34 | 1.34 |
| 376.74 | 3.33 | 3.33 |
| 261.15 | 2.11 | 2.11 |
| 293.22 | 2.28 | 2.28 |
| 219.12 | 0.70 | 0.70 |
| 219.12 | 0.70 | 0.70 |
| 275.18 | 2.36 | 2.36 |
| 255.15 | 1.54 | 1.54 |
| 271.15 | 1.65 | 1.65 |
| 233.14 | 0.95 | 0.95 |
| 339.29 | 3.94 | 3.94 |
| 277.22 | 2.58 | 2.58 |
| 360.67 | 2.86 | 2.86 |