Basic Information
ID: ALA4151495
Type: Binding
Description: Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cells assessed as reduction in ATP-dependent ULight-4E-BP1 (Thr37/Thr46) substrate peptide phosphorylation pre-incubated for 60 mins by LANCE Ultra assay
Organism: Homo sapiens
Cell type: Sf9
Activity Charts
Bioactivity
Activity Types for Assay ALA4151495
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 466.54 | 4.35 | 4.35 |
| 440.55 | 4.81 | 4.81 |
| 414.51 | 4.13 | 4.13 |
| 532.65 | 5.46 | 5.46 |
| 372.48 | 3.43 | 3.43 |
| 422.51 | 2.62 | 2.62 |
| 458.27 | -0.36 | -0.36 |
| 511.67 | 5.87 | 5.87 |
| 504.64 | 5.74 | 5.74 |
| 532.65 | 5.46 | 5.46 |
| 372.48 | 4.19 | 4.19 |
| 532.65 | 5.46 | 5.46 |
| 427.53 | 2.76 | 2.76 |
| 421.53 | 3.22 | 3.22 |
| 430.51 | 4.35 | 4.35 |
| 414.51 | 4.13 | 4.13 |
| 425.54 | 5.09 | 5.09 |
| 386.46 | 3.07 | 3.07 |
| 422.51 | 2.62 | 2.62 |
| 506.61 | 5.92 | 5.92 |
| 502.62 | 6.15 | 6.15 |
| 397.50 | 2.75 | 2.75 |
| 505.63 | 5.49 | 5.49 |
| 422.51 | 2.62 | 2.62 |
| 443.56 | 4.31 | 4.31 |
| 532.65 | 5.46 | 5.46 |
| 450.57 | 3.54 | 3.54 |
| 505.63 | 5.49 | 5.49 |
| 465.50 | 3.77 | 3.77 |
| 436.54 | 2.64 | 2.64 |