Poison activity at calf thymus TOP1 assessed as trapping of transient enzyme-DNA covalent complex by measuring ratio of nicked DNA at 25 uM using supe...

Basic Information

ID: ALA4154347

Type: Binding

Description: Poison activity at calf thymus TOP1 assessed as trapping of transient enzyme-DNA covalent complex by measuring ratio of nicked DNA at 25 uM using supercoiled pBR322 DNA after 30 mins by agarose gel electrophoresis (Rvb = 47%)

Format: BAO_0000357

Organism: Bos taurus

Target: Topoisomerase I(ALA6023)

Document: ALA4152240

Poison activity at calf thymus TOP1 assessed as trapping of transient enzyme-DNA covalent complex by measuring ratio of nicked DNA at 25 uM using supercoiled pBR322 DNA after 30 mins by agarose gel electrophoresis (Rvb = 47%): 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4154347

Activity

Total(4)

Parent Molecular Weight	ALogP	Polar Surface Area
348.36	2.08	2.08
407.40	2.50	2.50
421.43	2.89	2.89
435.46	3.28	3.28

Parent Molecular Weight

ALogP

Polar Surface Area

348.36

2.08

407.40

2.50

421.43

2.89

435.46

3.28

Poison activity at calf thymus TOP1 assessed as trapping of transient enzyme-DNA covalent complex by measuring ratio of nicked DNA at 25 uM using supe...

Basic Information

Activity Charts

Compound Summary