Inhibition of His-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli BL21(DE3) at 5 uM using SGRGK(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(...

Basic Information

ID: ALA4154434

Type: Binding

Description: Inhibition of His-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli BL21(DE3) at 5 uM using SGRGK(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K-Biotin as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins by Alphascreen assay relative to control

Format: BAO_0000019

Organism: Homo sapiens

Target: Bromodomain-containing protein 4(ALA1163125)

Document: ALA4152245

Inhibition of His-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli BL21(DE3) at 5 uM using SGRGK(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K-Biotin as substrate preincubated for 15 mins followed by substrate addition measured after 10 mins by Alphascreen assay relative to control: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4154434

Inhibition

Total(51)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
362.41	1.66	1.66
382.44	3.63	3.63
330.41	2.60	2.60
320.37	1.09	1.09
390.46	2.30	2.30
445.54	3.11	3.11
334.40	1.48	1.48
473.60	3.75	3.75
389.43	1.48	1.48
345.42	1.54	1.54
346.41	1.58	1.58
373.48	2.18	2.18
344.39	2.13	2.13
463.56	3.92	3.92
465.53	3.32	3.32
459.57	3.50	3.50
424.48	2.79	2.79
334.35	1.18	1.18
449.53	3.61	3.61
360.44	1.97	1.97
360.39	1.67	1.67
360.44	2.23	2.23
360.44	1.97	1.97
344.44	2.99	2.99
362.41	1.66	1.66
360.44	1.97	1.97
360.44	1.97	1.97
346.41	1.84	1.84
388.45	2.15	2.15
359.45	1.93	1.93
332.43	2.85	2.85
345.42	1.54	1.54
483.98	4.27	4.27
376.43	2.21	2.21
360.44	2.23	2.23
438.51	2.88	2.88
445.54	3.11	3.11
374.42	2.06	2.06
463.56	3.92	3.92
459.57	3.50	3.50
346.41	1.58	1.58
359.45	1.93	1.93
387.46	1.67	1.67
465.53	3.32	3.32
459.57	3.50	3.50
348.38	1.57	1.57
316.38	2.21	2.21
388.45	0.96	0.96
359.45	1.93	1.93
346.41	1.58	1.58
344.44	2.99	2.99