Basic Information
ID: ALA4155233
Type: Binding
Description: Antagonist activity at human TLR4 expressed in HEK blue cells coexpressing MD-2/CD14 assessed as inhibition of LPS-induced NF-kappaB activation-mediated SEAP production after 24 hrs
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4155233
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 406.48 | 3.74 | 3.74 |
| 458.00 | 4.47 | 4.47 |
| 420.51 | 4.13 | 4.13 |
| 348.41 | 3.01 | 3.01 |
| 408.50 | 5.84 | 5.84 |
| 442.00 | 4.77 | 4.77 |
| 462.51 | 4.95 | 4.95 |
| 503.05 | 5.71 | 5.71 |
| 472.03 | 4.86 | 4.86 |
| 472.03 | 4.86 | 4.86 |
| 361.44 | 2.50 | 2.50 |
| 451.61 | 4.52 | 4.52 |
| 382.46 | 5.33 | 5.33 |
| 489.02 | 5.40 | 5.40 |
| 484.08 | 5.76 | 5.76 |
| 420.51 | 5.74 | 5.74 |
| 445.97 | 4.60 | 4.60 |
| 375.46 | 2.89 | 2.89 |
| 470.06 | 5.42 | 5.42 |
| 470.96 | 6.06 | 6.06 |
| 350.39 | 4.31 | 4.31 |
| 486.59 | 5.19 | 5.19 |
| 456.03 | 5.03 | 5.03 |
| 455.57 | 4.35 | 4.35 |
| 503.05 | 5.71 | 5.71 |
| 517.07 | 6.10 | 6.10 |
| 468.60 | 5.05 | 5.05 |