Basic Information
ID: ALA4155442
Type: Functional
Description: Antagonist activity at Smo receptor in mouse NIH/3T3 cells harboring GRE-Luc assessed as inhibition of SAG-induced Hh signaling pathway preincubated with cells followed by SAG addition measured after 48 hrs by luciferase reporter gene assay
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA4155442
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 421.31 | 4.71 | 4.71 |
| 438.60 | 3.99 | 3.99 |
| 485.53 | 3.37 | 3.37 |
| 447.56 | 4.31 | 4.31 |
| 466.61 | 3.06 | 3.06 |
| 493.68 | 4.56 | 4.56 |
| 531.01 | 3.28 | 3.28 |
| 452.63 | 4.24 | 4.24 |
| 502.45 | 6.89 | 6.89 |
| 473.58 | 5.57 | 5.57 |
| 436.41 | 3.13 | 3.13 |
| 464.64 | 4.52 | 4.52 |
| 456.47 | 4.38 | 4.38 |
| 516.57 | 4.57 | 4.57 |
| 470.50 | 3.97 | 3.97 |
| 470.55 | 5.01 | 5.01 |
| 492.69 | 5.16 | 5.16 |
| 478.67 | 4.91 | 4.91 |
| 453.59 | 5.11 | 5.11 |
| 493.68 | 4.56 | 4.56 |
| 468.63 | 3.35 | 3.35 |
| 499.58 | 4.85 | 4.85 |
| 464.01 | 5.71 | 5.71 |
| 506.64 | 4.60 | 4.60 |
| 424.57 | 3.60 | 3.60 |
| 436.59 | 3.74 | 3.74 |
| 471.56 | 2.57 | 2.57 |
| 492.52 | 4.49 | 4.49 |
| 479.90 | 4.86 | 4.86 |
| 450.61 | 3.99 | 3.99 |
| 490.59 | 2.98 | 2.98 |
| 451.47 | 5.55 | 5.55 |
| 450.61 | 4.09 | 4.09 |
| 551.08 | 3.68 | 3.68 |