Inhibition of CYP1A2 in human liver microsomes assessed as reduction in formation of phenacetin to acetaminophen at 50 uM preincubated for 30 mins fol...

Basic Information

ID: ALA4178615

Type: ADME

Description: Inhibition of CYP1A2 in human liver microsomes assessed as reduction in formation of phenacetin to acetaminophen at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis

Format: BAO_0000251

Organism: Homo sapiens

Tissue: Liver

Subcellular Fraction: microsomes

Target:  Cytochrome P450 1A2(ALA3356)

Document:  ALA4177553

Inhibition of CYP1A2 in human liver microsomes assessed as reduction in formation of phenacetin to acetaminophen at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis: 1

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
883.851.271.27
867.852.162.16
805.781.031.03
873.810.860.86
857.811.751.75