Basic Information
ID: ALA4178617
Type: ADME
Description: Inhibition of CYP2C19 in human liver microsomes assessed as reduction in formation of mephenytoin to 4-Hydroxy mephenytoin at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Target: Cytochrome P450 2C19(ALA3622)
Document: ALA4177553
Inhibition of CYP2C19 in human liver microsomes assessed as reduction in formation of mephenytoin to 4-Hydroxy mephenytoin at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4178617
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 883.85 | 1.27 | 1.27 |
| 867.85 | 2.16 | 2.16 |
| 805.78 | 1.03 | 1.03 |
| 873.81 | 0.86 | 0.86 |
| 857.81 | 1.75 | 1.75 |