Basic Information
ID: ALA4178618
Type: ADME
Description: Inhibition of CYP2D6 in human liver microsomes assessed as reduction in formation of dextromethorphan to dextrorphan at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Target: Cytochrome P450 2D6(ALA289)
Document: ALA4177553
Inhibition of CYP2D6 in human liver microsomes assessed as reduction in formation of dextromethorphan to dextrorphan at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4178618
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 883.85 | 1.27 | 1.27 |
| 867.85 | 2.16 | 2.16 |
| 805.78 | 1.03 | 1.03 |
| 873.81 | 0.86 | 0.86 |
| 857.81 | 1.75 | 1.75 |