Basic Information
ID: ALA4178618
Type: ADME
Description: Inhibition of CYP2D6 in human liver microsomes assessed as reduction in formation of dextromethorphan to dextrorphan at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4178618
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 883.85 | 1.27 | 1.27 |
| 867.85 | 2.16 | 2.16 |
| 805.78 | 1.03 | 1.03 |
| 873.81 | 0.86 | 0.86 |
| 857.81 | 1.75 | 1.75 |