Basic Information
ID: ALA4178621
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes assessed as reduction in formation of midazolam to 1-Hydroxy midazolam at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of varying levels of NADPH by UPLC-MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4178621
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 805.78 | 1.03 | 1.03 |
| 873.81 | 0.86 | 0.86 |
| 857.81 | 1.75 | 1.75 |