Basic Information
ID: ALA4181291
Type: Binding
Description: Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 production pretreated for 30 mins followed by IL-1beta addition measured after 16 to 20 hrs by HTRF method
Organism: Homo sapiens
Cell type: A549
Activity Charts
Bioactivity
Activity Types for Assay ALA4181291
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 518.90 | 7.08 | 7.08 |
| 523.29 | 6.25 | 6.25 |
| 485.35 | 6.72 | 6.72 |
| 467.36 | 6.58 | 6.58 |
| 501.90 | 6.40 | 6.40 |
| 488.42 | 6.03 | 6.03 |
| 445.35 | 5.47 | 5.47 |
| 535.35 | 7.60 | 7.60 |
| 486.33 | 6.11 | 6.11 |
| 468.89 | 6.20 | 6.20 |
| 533.05 | 8.11 | 8.11 |
| 458.35 | 6.13 | 6.13 |
| 554.33 | 7.13 | 7.13 |
| 519.31 | 7.94 | 7.94 |
| 533.05 | 8.11 | 8.11 |
| 536.34 | 6.99 | 6.99 |
| 474.39 | 5.78 | 5.78 |
| 536.34 | 6.99 | 6.99 |