Basic Information
ID: ALA4181295
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-Hydroxy-testosterone formation at 10 uM measured after 20 mins in presence of NADPH by LC-MS/MS analysis relative to control
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4181295
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 518.90 | 7.08 | 7.08 |
| 523.29 | 6.25 | 6.25 |
| 501.90 | 6.40 | 6.40 |
| 535.35 | 7.60 | 7.60 |
| 533.05 | 8.11 | 8.11 |
| 519.31 | 7.94 | 7.94 |
| 536.34 | 6.99 | 6.99 |
| 536.34 | 6.99 | 6.99 |