Basic Information
ID: ALA4181721
Type: Binding
Description: Inhibition of recombinant Cav3.3 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Voltage-gated T-type calcium channel alpha-1I subunit(ALA5558)
Document: ALA4177680
Inhibition of recombinant Cav3.3 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by CaCl2 addition by Fluo-4-AM dye-based FLIPR assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4181721
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 368.39 | 3.66 | 3.66 |
| 291.35 | 3.11 | 3.11 |
| 424.45 | 3.64 | 3.64 |
| 335.41 | 3.51 | 3.51 |
| 427.45 | 4.21 | 4.21 |
| 381.39 | 3.28 | 3.28 |
| 369.42 | 4.26 | 4.26 |
| 368.87 | 3.83 | 3.83 |
| 381.39 | 3.28 | 3.28 |
| 418.42 | 4.08 | 4.08 |
| 443.43 | 4.02 | 4.02 |
| 359.43 | 3.05 | 3.05 |
| 399.40 | 3.17 | 3.17 |
| 370.40 | 3.46 | 3.46 |
| 406.40 | 3.15 | 3.15 |
| 349.41 | 3.60 | 3.60 |
| 377.44 | 4.00 | 4.00 |
| 387.46 | 4.01 | 4.01 |
| 384.43 | 4.08 | 4.08 |
| 446.43 | 4.09 | 4.09 |
| 427.45 | 3.81 | 3.81 |
| 397.47 | 4.75 | 4.75 |
| 417.41 | 4.90 | 4.90 |
| 325.80 | 3.77 | 3.77 |
| 369.42 | 4.51 | 4.51 |
| 366.37 | 3.87 | 3.87 |
| 305.38 | 3.42 | 3.42 |
| 443.43 | 3.88 | 3.88 |
| 398.37 | 2.84 | 2.84 |
| 348.45 | 3.49 | 3.49 |
| 401.39 | 3.59 | 3.59 |
| 366.37 | 3.62 | 3.62 |
| 320.40 | 3.12 | 3.12 |
| 429.40 | 3.63 | 3.63 |
| 352.41 | 3.32 | 3.32 |
| 335.41 | 3.43 | 3.43 |
| 383.44 | 4.19 | 4.19 |
| 400.43 | 3.78 | 3.78 |
| 382.37 | 2.67 | 2.67 |
| 366.44 | 3.88 | 3.88 |
| 415.42 | 3.33 | 3.33 |
| 369.39 | 3.77 | 3.77 |
| 387.46 | 4.01 | 4.01 |
| 321.38 | 3.12 | 3.12 |
| 433.41 | 4.57 | 4.57 |
| 371.39 | 2.85 | 2.85 |
| 381.39 | 3.28 | 3.28 |
| 325.80 | 3.77 | 3.77 |
| 366.37 | 3.87 | 3.87 |
| 305.38 | 3.42 | 3.42 |
| 415.38 | 3.59 | 3.59 |
| 277.33 | 3.18 | 3.18 |
| 391.48 | 3.14 | 3.14 |
| 401.39 | 3.33 | 3.33 |
| 348.45 | 3.49 | 3.49 |
| 393.44 | 4.71 | 4.71 |
| 417.51 | 3.31 | 3.31 |
| 426.35 | 3.73 | 3.73 |
| 433.41 | 3.63 | 3.63 |
| 375.35 | 4.01 | 4.01 |
| 305.38 | 3.42 | 3.42 |
| 397.43 | 3.68 | 3.68 |
| 364.45 | 3.19 | 3.19 |
| 400.43 | 3.47 | 3.47 |
| 386.47 | 5.32 | 5.32 |
| 347.42 | 3.61 | 3.61 |
| 334.42 | 3.18 | 3.18 |
| 425.41 | 3.97 | 3.97 |
| 382.37 | 2.42 | 2.42 |
| 348.45 | 3.49 | 3.49 |
| 377.42 | 3.19 | 3.19 |
| 433.41 | 3.38 | 3.38 |
| 380.40 | 5.05 | 5.05 |
| 373.46 | 3.68 | 3.68 |
| 333.44 | 4.24 | 4.24 |