Basic Information
ID: ALA4185348
Type: ADME
Description: Substrate activity at CYP3A5 in human liver microsomes assessed as enzyme-mediated benzoic acid (6R,7S)-2,6,10-trihydroxy-1,3,11,12-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-dibenzo[a,c]cycloocten-5-yl ester formation preincubated for 3 mins followed by NADPH addition measured after 20 mins by UFLC-DAD analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4185348
Drug metabolism
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 538.59 | 4.94 | 4.94 |