Basic Information
ID: ALA4186119
Type: Binding
Description: Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assay
Organism: Homo sapiens
Cell type: PBMC
Activity Charts
Bioactivity
Activity Types for Assay ALA4186119
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 498.61 | 2.76 | 2.76 |
| 554.67 | 3.31 | 3.31 |
| 443.53 | 3.07 | 3.07 |
| 429.50 | 2.68 | 2.68 |
| 514.63 | 2.61 | 2.61 |
| 540.64 | 2.88 | 2.88 |
| 415.47 | 2.30 | 2.30 |
| 512.59 | 2.24 | 2.24 |
| 570.67 | 2.50 | 2.50 |
| 567.67 | 2.96 | 2.96 |
| 457.51 | 2.07 | 2.07 |
| 538.63 | 2.68 | 2.68 |
| 540.64 | 2.88 | 2.88 |
| 441.51 | 2.83 | 2.83 |
| 569.68 | 2.22 | 2.22 |
| 512.59 | 2.21 | 2.21 |
| 482.56 | 1.91 | 1.91 |
| 512.59 | 2.14 | 2.14 |
| 524.60 | 2.29 | 2.29 |
| 455.54 | 3.22 | 3.22 |
| 542.61 | 2.90 | 2.90 |
| 552.58 | 3.30 | 3.30 |
| 455.54 | 3.22 | 3.22 |
| 516.55 | 2.04 | 2.04 |
| 469.56 | 3.61 | 3.61 |
| 401.44 | 1.91 | 1.91 |
| 512.59 | 2.21 | 2.21 |
| 427.48 | 2.44 | 2.44 |
| 526.62 | 2.49 | 2.49 |
| 554.67 | 3.26 | 3.26 |
| 526.62 | 2.53 | 2.53 |
| 540.64 | 2.92 | 2.92 |
| 512.63 | 3.15 | 3.15 |
| 498.56 | 1.90 | 1.90 |
| 395.44 | -0.14 | -0.14 |
| 512.59 | 2.15 | 2.15 |
| 441.51 | 2.83 | 2.83 |
| 512.59 | 2.29 | 2.29 |