Inhibition of C-terminal 6-His tagged recombinant Clostridium difficile toxin B catalytic fragment (Met1 to Leu543 residues) assessed as reduction in ...

Basic Information

ID: ALA4187427

Type: Binding

Description: Inhibition of C-terminal 6-His tagged recombinant Clostridium difficile toxin B catalytic fragment (Met1 to Leu543 residues) assessed as reduction in glucosyltransferase domain UDP-glucose hydrolysis activity using UDP-glucose and ADP Alexa633 tracer incubated fore 3 hrs by fluorescence polarization assay

Format: BAO_0000357

Organism: Clostridioides difficile

Target: Toxin B(ALA3580505)

Document: ALA4184209

Inhibition of C-terminal 6-His tagged recombinant Clostridium difficile toxin B catalytic fragment (Met1 to Leu543 residues) assessed as reduction in glucosyltransferase domain UDP-glucose hydrolysis activity using UDP-glucose and ADP Alexa633 tracer incubated fore 3 hrs by fluorescence polarization assay: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4187427

IC50

Total(45)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
448.91	4.63	4.63
511.97	4.59	4.59
511.97	4.59	4.59
511.97	4.59	4.59
420.85	4.37	4.37
419.41	3.12	3.12
448.91	4.55	4.55
503.77	5.55	5.55
400.86	4.05	4.05
459.89	4.12	4.12
435.87	3.64	3.64
502.79	4.95	4.95
435.87	3.64	3.64
449.89	3.66	3.66
483.35	5.21	5.21
515.96	4.49	4.49
448.91	4.55	4.55
358.78	3.02	3.02
401.42	2.99	2.99
450.88	3.95	3.95
512.96	3.98	3.98
469.32	4.90	4.90
448.91	4.55	4.55
469.32	4.90	4.90
450.88	3.95	3.95
435.87	3.64	3.64
435.87	3.64	3.64
518.00	4.65	4.65
511.97	4.59	4.59
435.87	3.64	3.64
469.32	4.90	4.90
469.32	4.90	4.90
440.93	4.97	4.97
542.98	3.99	3.99
436.86	3.03	3.03
512.96	3.98	3.98
526.00	4.90	4.90
435.87	3.64	3.64
542.00	4.60	4.60
441.90	3.70	3.70
510.98	5.19	5.19
431.45	2.99	2.99
434.88	4.24	4.24
449.89	3.73	3.73
452.87	4.38	4.38