Basic Information
ID: ALA4187608
Type: Binding
Description: Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release at 20 uM pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 67 nM enzyme and chromogenic substrate S-2288 by spectrophotometry
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4187608
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 478.84 | 4.44 | 4.44 |
| 449.83 | 3.42 | 3.42 |
| 428.83 | 2.82 | 2.82 |
| 428.83 | 3.89 | 3.89 |
| 380.76 | 2.77 | 2.77 |
| 398.80 | 3.55 | 3.55 |
| 371.78 | 4.32 | 4.32 |
| 482.92 | 4.62 | 4.62 |
| 461.84 | 3.69 | 3.69 |
| 470.88 | 4.75 | 4.75 |
| 442.86 | 3.57 | 3.57 |
| 476.32 | 3.69 | 3.69 |
| 444.90 | 4.36 | 4.36 |
| 398.80 | 4.27 | 4.27 |
| 439.86 | 3.69 | 3.69 |
| 384.78 | 3.88 | 3.88 |
| 456.86 | 4.44 | 4.44 |
| 482.92 | 4.62 | 4.62 |
| 509.95 | 4.57 | 4.57 |
| 428.83 | 3.89 | 3.89 |
| 439.86 | 3.69 | 3.69 |
| 429.82 | 3.29 | 3.29 |
| 428.83 | 3.02 | 3.02 |
| 429.82 | 3.29 | 3.29 |
| 444.90 | 4.61 | 4.61 |
| 478.84 | 4.44 | 4.44 |
| 430.77 | 3.65 | 3.65 |
| 429.82 | 3.29 | 3.29 |
| 461.84 | 3.69 | 3.69 |
| 522.00 | 3.93 | 3.93 |
| 482.92 | 4.62 | 4.62 |
| 428.83 | 3.89 | 3.89 |
| 355.78 | 4.48 | 4.48 |
| 341.75 | 4.55 | 4.55 |
| 498.94 | 5.16 | 5.16 |
| 442.86 | 3.03 | 3.03 |