Basic Information
ID: ALA4187618
Type: Binding
Description: Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release pre-incubated for 15 mins before 2 nM Spectrozyme tPA substrate addition for 15 mins using 5 nM enzyme and chromogenic substrate S-2288 by spectrophotometry
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4187618
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 351.79 | 4.96 | 4.96 |
| 409.91 | 5.76 | 5.76 |
| 424.82 | 5.51 | 5.51 |
| 424.82 | 5.51 | 5.51 |
| 424.82 | 5.51 | 5.51 |
| 379.80 | 4.52 | 4.52 |
| 359.81 | 4.18 | 4.18 |
| 424.82 | 5.51 | 5.51 |
| 409.91 | 5.76 | 5.76 |
| 381.26 | 3.89 | 3.89 |
| 367.79 | 5.08 | 5.08 |
| 333.77 | 4.08 | 4.08 |
| 377.23 | 4.08 | 4.08 |
| 374.76 | 4.35 | 4.35 |
| 357.82 | 5.02 | 5.02 |
| 357.84 | 5.34 | 5.34 |
| 331.80 | 4.59 | 4.59 |
| 401.85 | 6.11 | 6.11 |
| 351.79 | 4.96 | 4.96 |
| 357.84 | 5.34 | 5.34 |
| 355.82 | 5.25 | 5.25 |