Basic Information
ID: ALA4189731
Type: Functional
Description: In vivo inhibition of BTK in human TMD8 cells xenografted in CB17 SCID nude mouse assessed as decrease in PLCgamma2 phosphorylation at Y759 at 15 mg/kg, po qd administered for 13 consecutive days measured on day 17 by Western blot method
Format: BAO_0000218
Organism: Mus musculus
Strain: CB17
Cell type: TMD8
Target: Mus musculus(ALA375)
Document: ALA4184325
In vivo inhibition of BTK in human TMD8 cells xenografted in CB17 SCID nude mouse assessed as decrease in PLCgamma2 phosphorylation at Y759 at 15 mg/kg, po qd administered for 13 consecutive days measured on day 17 by Western blot method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4189731
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 423.48 | 4.17 | 4.17 |