Basic Information
ID: ALA4190137
Type: ADME
Description: Inhibition of C-terminal His-tagged recombinant human CYP21A2deltaH mutant expressed in Escherichia coli DH5alpha assessed as decrease in progesterone hydroxylation preincubated for 3 mins followed by NADPH addition measured after 10 mins in presence of cytochrome p450 reductase by LC-MS/MS method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4190137
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 347.50 | 5.61 | 5.61 |
| 349.52 | 5.40 | 5.40 |
| 388.56 | 5.81 | 5.81 |
| 348.53 | 6.00 | 6.00 |
| 365.52 | 4.66 | 4.66 |
| 374.53 | 5.29 | 5.29 |
| 392.54 | 4.25 | 4.25 |
| 363.55 | 5.48 | 5.48 |
| 380.53 | 3.96 | 3.96 |
| 367.53 | 4.45 | 4.45 |
| 380.53 | 4.92 | 4.92 |