Basic Information
ID: ALA4191460
Type: Binding
Description: Inhibition of P-gp in human KBv200 cells assessed as increase in intracellular rhodamine123 accumulation by measuring fluorescence activity ratio at 10 uM incubated for 4 hrs followed by rhodamine123 addition measured after 1 hr by flow cytometry
Format: BAO_0000219
Organism: Homo sapiens
Target: Unchecked(ALA612545)
Document: ALA4190209
Inhibition of P-gp in human KBv200 cells assessed as increase in intracellular rhodamine123 accumulation by measuring fluorescence activity ratio at 10 uM incubated for 4 hrs followed by rhodamine123 addition measured after 1 hr by flow cytometry: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4191460
Ratio
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 316.44 | 3.77 | 3.77 |
| 234.34 | 3.62 | 3.62 |
| 464.60 | 4.74 | 4.74 |
| 438.56 | 4.34 | 4.34 |
| 456.71 | 6.63 | 6.63 |
| 314.43 | 3.98 | 3.98 |
| 360.49 | 3.83 | 3.83 |
| 480.60 | 3.71 | 3.71 |
| 456.58 | 2.98 | 2.98 |
| 376.49 | 2.80 | 2.80 |
| 440.67 | 6.45 | 6.45 |
| 456.71 | 6.63 | 6.63 |
| 456.58 | 2.98 | 2.98 |
| 523.67 | 3.53 | 3.53 |
| 376.49 | 2.80 | 2.80 |
| 372.55 | 4.86 | 4.86 |
| 438.56 | 3.93 | 3.93 |
| 482.62 | 3.38 | 3.38 |
| 454.56 | 3.31 | 3.31 |
| 454.70 | 6.67 | 6.67 |
| 456.58 | 2.98 | 2.98 |
| 412.61 | 5.67 | 5.67 |
| 316.44 | 2.87 | 2.87 |
| 438.56 | 4.10 | 4.10 |
| 438.56 | 4.10 | 4.10 |